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FOXP3 抗体

Cited in 2+ publications. This 小鼠 单克隆 anti-FOXP3 antibody (Clone 4C7) specifically detects FOXP3 in ELISA. The antibody is reactive with 人 samples.
产品编号 ABIN969156
发货至: 中国
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中国
北京 101111
No. 88 KeChuang 6th Street
Beijing Economic Technological Development Area
Room 801-803
4A Biotech Co.,Ltd.
Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for FOXP3 抗体 (ABIN969156)

抗原

See all FOXP3 抗体
FOXP3 (Forkhead Box P3 (FOXP3))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This FOXP3 antibody is un-conjugated

应用范围

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ELISA

克隆位点

4C7
  • 原理

    FOXP3 Antibody

    纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of human FOXP3 expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    ELISA: 1/10000

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    Ascitic fluid containing 0.03 % sodium azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Yuan, Chen, Li, Dong, Xue, Wang, Zhang, Wang, Zhang, Ge, Shen, Xu: "Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner." in: Clinical immunology (Orlando, Fla.), Vol. 134, Issue 3, pp. 277-88, (2010) (PubMed).

    Sarigul, Yazisiz, Bassorgun, Ulker, Avci, Erbasan, Gelen, Gorczynski, Terzioglu: "The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome." in: Lupus, Vol. 19, Issue 2, pp. 138-45, (2010) (PubMed).

  • 抗原

    FOXP3 (Forkhead Box P3 (FOXP3))

    别名

    FOXP3

    背景

    FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.

    分子量

    47.2 kDa

    UniProt

    Q9BZS1

    途径

    Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
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