FOXP3 抗体
Quick Overview for FOXP3 抗体 (ABIN969156)
抗原
See all FOXP3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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原理
- FOXP3 Antibody
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纯化方法
- Ascitic fluid
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免疫原
- Purified recombinant fragment of human FOXP3 expressed in E. Coli.
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亚型
- IgG1
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应用备注
- ELISA: 1/10000
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- Ascitic fluid containing 0.03 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner." in: Clinical immunology (Orlando, Fla.), Vol. 134, Issue 3, pp. 277-88, (2010) (PubMed).
: "The numbers of Foxp3 + Treg cells are positively correlated with higher grade of infiltration at the salivary glands in primary Sjogren's syndrome." in: Lupus, Vol. 19, Issue 2, pp. 138-45, (2010) (PubMed).
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Elevated expression of Foxp3 in tumor-infiltrating Treg cells suppresses T-cell proliferation and contributes to gastric cancer progression in a COX-2-dependent manner." in: Clinical immunology (Orlando, Fla.), Vol. 134, Issue 3, pp. 277-88, (2010) (PubMed).
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- FOXP3 (Forkhead Box P3 (FOXP3))
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别名
- FOXP3
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背景
- FOXP3 (a 431 amino acid protein) is a member of the forkhead/winged-helix family of transcriptional regulators and is highly conserved across mammals. FOXP3 is essential for normal immune homeostasis. FOXP3 is stably and constitutively expressed at a high level in CD25 + CD4 positive regulatory T cells, at low level in CD4 positive/CD25 negative cells, and is absent in CD4 negative/CD8 positive T cells. FOXP3 may be a master regulatory gene and a more specific marker of regulatory T cells than other T cells.
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分子量
- 47.2 kDa
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UniProt
- Q9BZS1
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途径
- Chromatin Binding, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Activated T Cell Proliferation
抗原
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