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Estrogen Receptor alpha 抗体

ESR1 适用: 人 WB, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 6B6 unconjugated
产品编号 ABIN969119
发货至: 中国
  • 抗原 See all Estrogen Receptor alpha (ESR1) 抗体
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    适用
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Estrogen Receptor alpha antibody is un-conjugated
    应用范围
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    Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC)
    原理
    ESR1 Antibody
    纯化方法
    Ascitic fluid
    免疫原
    Purified recombinant fragment of human ESR1 expressed in E. Coli.
    克隆位点
    6B6
    亚型
    IgG1
    Top Product
    Discover our top product ESR1 Primary Antibody
  • 应用备注

    ELISA: 1/10000

    ICC: 1/200 - 1/1000

    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    Ascitic fluid containing 0.03 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Deegan, Seldeen, McDonald, Bhat, Farooq: "Binding of the ERalpha nuclear receptor to DNA is coupled to proton uptake." in: Biochemistry, Vol. 49, Issue 29, pp. 5978-88, (2010) (PubMed).

    Harsløf, Husted, Carstens, Stenkjaer, Langdahl: "Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis." in: Calcified tissue international, Vol. 87, Issue 1, pp. 25-35, (2010) (PubMed).

  • 抗原
    Estrogen Receptor alpha (ESR1) (Estrogen Receptor 1 (ESR1))
    别名
    ESR1 (ESR1 产品)
    背景

    Description: This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis.

    Aliases: ER, ESR, Era, ESRA, NR3A1, DKFZp686N23123, ESR1

    分子量
    66kDa
    基因ID
    2099
    HGNC
    2099
    UniProt
    P03372
    途径
    Nuclear Receptor Transcription Pathway, EGFR Signaling Pathway, Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Steroid Hormone Mediated Signaling Pathway, Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly
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