STAT4 抗体 (pTyr693)
(2 references)Quick Overview for STAT4 抗体 (pTyr693) (ABIN968925)
抗原
See all STAT4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- pTyr693
-
交叉反应
- 小鼠
-
产品特性
-
1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
-
免疫原
- Phosphorylated Human Stat4 (pY693)
-
亚型
- IgG2b kappa
-
-
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 505-737) antibody
STAT4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 1-748) antibodySTAT4 适用: 人 WB, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 1C2-1C12 unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 600-700) antibodySTAT4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 569-748) antibodySTAT4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (pTyr693) antibodySTAT4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) antibodySTAT4 适用: 人 WB, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (N-Term) antibodySTAT4 适用: 人, 小鼠, 大鼠, Pig, 犬, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (C-Term) antibodySTAT4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (pTyr693) antibodySTAT4 适用: 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 1-749) antibodySTAT4 适用: 人 WB, IHC, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 1C2-1C12 unconjugated
-
-
说明
-
Related Products: ABIN967389
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 250 μg/mL
-
缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store undiluted at -20°C.
-
-
-
: "Signaling through the JAK/STAT pathway, recent advances and future challenges." in: Gene, Vol. 285, Issue 1-2, pp. 1-24, (2002) (PubMed).
: "Importance of the MKK6/p38 pathway for interleukin-12-induced STAT4 serine phosphorylation and transcriptional activity." in: Blood, Vol. 96, Issue 5, pp. 1844-52, (2000) (PubMed).
-
: "Signaling through the JAK/STAT pathway, recent advances and future challenges." in: Gene, Vol. 285, Issue 1-2, pp. 1-24, (2002) (PubMed).
-
- STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
-
别名
- Stat4
-
背景
- The Stat proteins function both as cytoplasmic signal transducers and as activators of transcription. Seven mammalian Stat proteins have been identified: Stat1-4, Stat5a, 5b, and Stat6. Stat4 has been shown to play an important role in development of T helper cells, specifically the Th1 subset. Stat4 is activated by IL-12 and by type 1 interferons. Knockout mice supported the role that Stat4 plays in IL-12 signaling because lymphocytes from Stat 4-/- mice could not differentiate into Th1 cells or produce IFNgamma in response to treatment with IL-12. IFNgamma plays an important role in host defense. A key component in the activation of Stat4 is the phosphorylation on tyrosine and serine residues in response to IL-12 stimulation. IL-12 stimulation leads to the phosphorylation of Stat4 on tyrosine 693 and serine 721. Transcriptional activity of Stat4 has been shown to be significantly reduced when residues Y693 and S721 are mutated.
-
分子量
- 89 kDa
-
途径
- JAK/STAT Signaling
抗原
-
