LIMS1 抗体 (AA 120-220)
(3 references)Quick Overview for LIMS1 抗体 (AA 120-220) (ABIN968921)
抗原
See all LIMS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 120-220
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交叉反应
- 大鼠, 小鼠
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无交叉反应
- 犬, 小鸡
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human PINCH aa. 120-220
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亚型
- IgG2a
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anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibody
LIMS1 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 5G7 unconjugated
anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) (AA 1-325) antibodyLIMS1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibodyLIMS1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibodyLIMS1 适用: 人, 小鼠, 大鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibodyLIMS1 适用: 人, 小鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) (AA 68-303) antibodyLIMS1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1) antibodyLIMS1 适用: 人, 小鼠, 大鼠 WB, IF, IC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968586, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury." in: Glia, Vol. 41, Issue 3, pp. 213-23, (2003) (PubMed).
: "The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells." in: Molecular and cellular biology, Vol. 19, Issue 3, pp. 2425-34, (1999) (PubMed).
: "Nck-2, a novel Src homology2/3-containing adaptor protein that interacts with the LIM-only protein PINCH and components of growth factor receptor kinase-signaling pathways." in: Molecular biology of the cell, Vol. 9, Issue 12, pp. 3367-82, (1999) (PubMed).
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: "Identification of PINCH in Schwann cells and DRG neurons: shuttling and signaling after nerve injury." in: Glia, Vol. 41, Issue 3, pp. 213-23, (2003) (PubMed).
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- LIMS1 (LIM and Senescent Cell Antigen-Like Domains 1 (LIMS1))
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别名
- PINCH
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背景
- Integrins are transmembrane receptors that mediate cell-cell or cell-matrix adhesion. All integrins are heterodimers composed of alpha and beta subunits, which interact with extracellular matrix and cytoskeletal proteins. Signal transduction through intergin receptors may be regulated by integrin-linked kinase (ILK). ILK is a widely expressed Ser/Thr protein kinase that contains four ankyrin-like repeats in the N-terminal region, a phoshoinositide lipid-binding motif at amino acids 180-212, and an integrin binding site at amino acids 293-451. The ankyrin repeats interact with a LIM domain-only protein called PINCH that also binds the adaptor protein, Nck-2. This interaction implicates ILK in growth factor receptor pathways. The PINCH adaptor protein also contains a leucine-rich nuclear export signal and a nuclear localization signal. These two motifs implicate PINCH in nuclear functions, and in Schwann cells PINCH has been found in the nucleus, as well as, cytoplasm and perinuclear regions. Thus, PINCH is an adaptor protein that functions in both integrin signaling and nuclear functions.
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分子量
- 37 kDa
抗原
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