TRAP1 抗体 (AA 253-464)
(3 references)Quick Overview for TRAP1 抗体 (AA 253-464) (ABIN968825)
抗原
See all TRAP1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 253-464
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交叉反应
- 犬, 大鼠, 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Hsp75/TRAP1 aa. 253-464
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亚型
- IgG1
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anti-TNF Receptor-Associated Protein 1 (TRAP1) antibody
TRAP1 适用: 人, 大鼠, 小鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 1A1 unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) (AA 1-704) antibodyTRAP1 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) antibodyTRAP1 适用: 人, 大鼠, 犬, 猴 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 1H8 unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) (AA 445-704) antibodyTRAP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) antibodyKO Validated TRAP1 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) antibodyTRAP1 适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) (AA 60-308) antibodyTRAP1 适用: 人 WB, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) (Internal Region) antibodyTRAP1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) antibodyTRAP1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-TNF Receptor-Associated Protein 1 (TRAP1) (AA 1-704) antibodyTRAP1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
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说明
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Related Products: ABIN967389, ABIN968535
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties." in: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3305-12, (2000) (PubMed).
: "A new member of the hsp90 family of molecular chaperones interacts with the retinoblastoma protein during mitosis and after heat shock." in: Molecular and cellular biology, Vol. 16, Issue 9, pp. 4691-9, (1996) (PubMed).
: "Identification of a protein with homology to hsp90 that binds the type 1 tumor necrosis factor receptor." in: The Journal of biological chemistry, Vol. 270, Issue 8, pp. 3574-81, (1995) (PubMed).
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: "The hsp90-related protein TRAP1 is a mitochondrial protein with distinct functional properties." in: The Journal of biological chemistry, Vol. 275, Issue 5, pp. 3305-12, (2000) (PubMed).
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- TRAP1 (TNF Receptor-Associated Protein 1 (TRAP1))
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别名
- Hsp75
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背景
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The hsp90 family of molecular chaperones is involved in a number of signal transduction pathways, including cell division, protein folding and transport. A new member of this family was recently identified as TRAP1 (Tumor necrosis factor receptor-associated protein) or hsp75. TRAP1 is a mitochondrial protein that is an ATPase and ATP-binding protein, rendering it similar to hsp90. There is a high degree of homology between TRAP1 and hsp90 in 6 domains, however one major difference is that a highly charged domain present in hsp90 is absent in TRAP1. TRAP1 has been shown to interact with the intracellular domain of the type 1 receptor for tumor necrosis factor (TNFR-1IC) and to the retinoblastoma protein (Rb). Signaling through TNFR-1 induces antiviral responses, fibroblast proliferation, cytotoxicity, etc. TRAP1 binds TNFR-1IC outside of the death domain leading to disruption in the signaling by TNFR-1. Rb has been shown to play a pivotal role in cellular differentiation and progression through the cell cycle. TRAP1 associates with Rb via an LxCxE motif, which is common among proteins that interact with Rb through SV40 T-antigen binding domain. Thus, TRAP1 is a new member of the hsp90 family that interacts with Rb and TNFR-1IC.
Synonyms: TRAP1 -
分子量
- 75 kDa
抗原
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