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Transferrin Receptor 抗体 (AA 517- 623)

Name: Transferrin Receptor 抗体 (AA 517- 623)
SKU: ABIN968749
Availability: OutOfStock

TFRC 适用: 人 WB, IF 宿主: 小鼠 Monoclonal 2-Transferrin unconjugated

Western blot analysis of the transferrin receptor on a Jurkat cell lysate (Human T-cell leukemia, ATCC TIB-152). (Transferrin Receptor 抗体 (AA 517- 623))

1 image

(2 references)

产品编号 ABIN968749

发货至: 中国

Datasheet as PDF

抗原 See all Transferrin Receptor (TFRC) 抗体

Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))
抗原表位
16

15

10

8

8

7

6

6

6

5

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 517- 623
适用
187

76

27

7

6

4

2

2

2

1

1

1

1
人
宿主
108

101

26

1

1
小鼠
Compatible Secondaries
克隆类型
141

94

1
单克隆
标记
106

25

19

14

9

5

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1
This Transferrin Receptor antibody is un-conjugated
应用范围
140

137

69

68

50

39

23

20

18

12

7

6

3

3

2

2

1

1

1

1

1

1

1

1
Western Blotting (WB), Immunofluorescence (IF)

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human Transferrin Receptor aa. 517- 623

克隆位点

2-Transferrin

亚型

IgG1

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anti-Transferrin Receptor (p90, CD71) (TFRC) antibody
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anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 621-720) antibody
TFRC 适用: 人, 小鼠 FACS, WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 567-744) antibody
TFRC 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Transferrin Receptor (p90, CD71) (TFRC) (AA 572-757) antibody
TFRC 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968537, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Seiser, Posch, Thompson, Kühn: "Effect of transcription inhibitors on the iron-dependent degradation of transferrin receptor mRNA." in: The Journal of biological chemistry, Vol. 270, Issue 49, pp. 29400-6, (1996) (PubMed).

McClelland, Kühn, Ruddle: "The human transferrin receptor gene: genomic organization, and the complete primary structure of the receptor deduced from a cDNA sequence." in: Cell, Vol. 39, Issue 2 Pt 1, pp. 267-74, (1985) (PubMed).
抗原

Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

别名

Transferrin Receptor (TFRC 产品)

别名

Trfr antibody, LOC100219280 antibody, tfr antibody, cd71 antibody, tfr1 antibody, trfr antibody, CD71 antibody, T9 antibody, TFR antibody, TFR1 antibody, TR antibody, TRFR antibody, p90 antibody, 2610028K12Rik antibody, AI195355 antibody, AI426448 antibody, AU015758 antibody, E430033M20Rik antibody, Mtvr-1 antibody, Mtvr1 antibody, transferrin receptor antibody, TFRC antibody, Tfrc antibody, tfrc antibody

背景

Iron acquisition is a prerequisite for cell proliferation. The transferrin receptor is the primary mode of iron uptake. This receptor mediates iron uptake through internalization and recycling of the iron carrying serum protein transferrin. Binding of transferrin to its receptor causes rapid internalization into an acidic intracellular compartment where iron dissociates from transferrin. Both the receptor and transferrin are then recycled through the exocytic pathway. The transferrin receptor is expressed in most cells and tissues, especially proliferating cells, and the receptor is expressed as a dimer of identical intergral membrane proteins. Transferrin receptor mRNA expression is inversely proportional to iron availability, and this regulation occurs through post-transcriptional control of mRNA stability. Transferrin receptor mRNA contains iron responsive elements (IRE) that are bound by IRE-binding proteins (IRP). The RNA binding of IRPs is dependent on iron levels. Thus, iron deprivation leads to increased RNA binding, which masks the recognition site of endonucleases and stabilizes transferrin receptor mRNA. This antibody is routinely tested by western blot analysis.

分子量

85 kDa

途径

Transition Metal Ion Homeostasis