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MSH3 抗体 (AA 136-349)

Name: MSH3 抗体 (AA 136-349)
SKU: ABIN968513
Availability: OutOfStock

This anti-MSH3 antibody is a 小鼠单克隆 antibody detecting MSH3 in WB 和 IF. Suitable for 人. This Primary Antibody has been cited in 4+ publications.

Western blot analysis of MSH3 on a HeLa cell lysate (Human cervical epitheloid carcinoma, ATCC CCL-2). (MSH3 抗体 (AA 136-349))

Immunofluorescence staining of human fibroblasts. (MSH3 抗体 (AA 136-349))

Image no. 3 for anti-MutS Homolog 3 (MSH3) (AA 136-349) antibody (ABIN968513) (MSH3 抗体 (AA 136-349))

3 images

(4 references)

产品编号 ABIN968513

发货至: 中国

Datasheet as PDF

Quick Overview for MSH3 抗体 (AA 136-349) (ABIN968513)

抗原

See all MSH3 抗体

MSH3 (MutS Homolog 3 (MSH3))

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This MSH3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

52-MSH3

Discover our top product MSH3 Primary Antibody

抗原表位
15

5

2

1

1

1

1

1

1
AA 136-349

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human MSH3 aa. 136-349

亚型

IgG1
anti-MutS Homolog 3 (MSH3) (N-Term) antibody
MSH3 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (N-Term) antibody
MSH3 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (N-Term) antibody
MSH3 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (AA 651-750) antibody
MSH3 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (AA 521-620) antibody
MSH3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (N-Term) antibody
MSH3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (AA 51-100) antibody
MSH3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (AA 617-761) antibody
MSH3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (N-Term) antibody
MSH3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

anti-MutS Homolog 3 (MSH3) (AA 651-750) antibody (Biotin)
MSH3 适用: 人 ELISA, IHC (p), IHC (fro) 宿主: 兔 Polyclonal Biotin

说明

Related Products: ABIN967389, ABIN968535

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Wilson, Guerrette, Fishel: "Dissociation of mismatch recognition and ATPase activity by hMSH2-hMSH3." in: The Journal of biological chemistry, Vol. 274, Issue 31, pp. 21659-64, (1999) (PubMed).

Umar, Risinger, Glaab, Tindall, Barrett, Kunkel: "Functional overlap in mismatch repair by human MSH3 and MSH6." in: Genetics, Vol. 148, Issue 4, pp. 1637-46, (1998) (PubMed).

Watanabe, Ikejima, Suzuki, Shimada: "Genomic organization and expression of the human MSH3 gene." in: Genomics, Vol. 31, Issue 3, pp. 311-8, (1997) (PubMed).

New, Liu, Crouse: "The yeast gene MSH3 defines a new class of eukaryotic MutS homologues." in: Molecular & general genetics : MGG, Vol. 239, Issue 1-2, pp. 97-108, (1993) (PubMed).
抗原

MSH3 (MutS Homolog 3 (MSH3))

别名

MSH3

背景

Bacterial mismatch DNA repair involves the MutL, MutH, and MutS proteins, which forms a complex that mediates excision repair. Mutations in or deficiencies of any of these proteins results in a mutator phenotype that is characterized by genetic instability. Human homologs of MutS include MSH2, MSH3, and MSH6. MSH2 forms heterodimers with MSH6 (hMutSalpha) or MSH3 (hMutSbeta) that specifically bind single-mispaired nucleotides and a subset of insertion-deletion mismatches. In addition, these heterodimers have intrinsic ATPase activity that is regulated by mismatch binding. ADP-bound heterodimers bind mismatched nucleotides, while ATP-bound heterodimers do not. The role of MSH3 in genetic stability in human cells in unclear. However, MSH3 and MSH6 share roles in the control of mutation rates. Both participate in repair of replication errors containing base-base mismatches or 1-4 extra bases. The MSH3 gene is located upstream of the dihydrofolate reductase (DHFR) gene and is expressed at low levels in a variety of human tissues. Thus, MSH3 is a component of an adenosine nucleotide-regulated molecular switch whose activity is essential for classical nucleotide mismatch repair.

分子量

127 kDa

途径

DNA Damage Repair, Production of Molecular Mediator of Immune Response