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Endoglin 抗体 (AA 24-144)

Name: Endoglin 抗体 (AA 24-144)
SKU: ABIN968468
Availability: OutOfStock

This anti-Endoglin antibody is a 小鼠单克隆 antibody detecting Endoglin in WB 和 IF. Suitable for 人. This Primary Antibody has been cited in 4+ publications.

Western Blotting (WB) image for anti-Endoglin (ENG) (AA 24-144) antibody (ABIN968468) (Endoglin 抗体 (AA 24-144))

Immunofluoresent staining of ES2 cells with anti-CD105/endoglin antibody. (Endoglin 抗体 (AA 24-144))

Image no. 3 for anti-Endoglin (ENG) (AA 24-144) antibody (ABIN968468) (Endoglin 抗体 (AA 24-144))

Western blot analysis of CD105 on human endothelial cell lysate. (Endoglin 抗体 (AA 24-144))

4 images

(4 references)

产品编号 ABIN968468

发货至: 中国

Quick Overview for Endoglin 抗体 (AA 24-144) (ABIN968468)

抗原

See all Endoglin (ENG) 抗体

Endoglin (ENG)

适用

人

宿主

小鼠

克隆类型

单克隆

标记

This Endoglin antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

35-CD105

Discover our top product ENG Primary Antibody

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AA 24-144

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
4. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human S-Endoglin aa. 24-144

亚型

IgG1 kappa
anti-Endoglin (ENG) (AA 58-110) antibody
ENG 适用: 人, 小鼠, 大鼠, 犬 WB, FACS, ELISA, IHC (fro), IHC (p), IF (cc), IF (p) 宿主: 兔 Polyclonal unconjugated

anti-Endoglin (ENG) (AA 27-137) antibody
ENG 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Endoglin (ENG) (AA 26-136) antibody
ENG 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Endoglin (ENG) (AA 26-136) antibody
ENG 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Endoglin (ENG) antibody
ENG 适用: 人 FACS, IHC, ELISA, ICC 宿主: 小鼠 Monoclonal 3A9 unconjugated

anti-Endoglin (ENG) (AA 27-226) antibody
ENG 适用: 小鼠, 大鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

anti-Endoglin (ENG) (AA 601-658) antibody
ENG 适用: 人, 大鼠 ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-Endoglin (ENG) antibody
ENG 适用: 人, 大鼠 WB, FACS, IP, MS 宿主: 小鼠 Monoclonal MEM-226 unconjugated

anti-Endoglin (ENG) antibody (APC)
ENG 适用: 人, 大鼠 FACS 宿主: 小鼠 Monoclonal MEM-226 APC

anti-Endoglin (ENG) (AA 370-430) antibody
ENG 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968536, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20° C.
Barbara, Wrana, Letarte: "Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-beta superfamily." in: The Journal of biological chemistry, Vol. 274, Issue 2, pp. 584-94, (1999) (PubMed).

Li, Sorensen, Brooke, Urness, Davis, Taylor, Boak, Wendel: "Defective angiogenesis in mice lacking endoglin." in: Science (New York, N.Y.), Vol. 284, Issue 5419, pp. 1534-7, (1999) (PubMed).

Bellón, Corbí, Lastres, Calés, Cebrián, Vera, Cheifetz, Massague, Letarte, Bernabéu: "Identification and expression of two forms of the human transforming growth factor-beta-binding protein endoglin with distinct cytoplasmic regions." in: European journal of immunology, Vol. 23, Issue 9, pp. 2340-5, (1993) (PubMed).

Gougos, Letarte: "Primary structure of endoglin, an RGD-containing glycoprotein of human endothelial cells." in: The Journal of biological chemistry, Vol. 265, Issue 15, pp. 8361-4, (1990) (PubMed).
抗原

Endoglin (ENG)

别名

CD105

背景

Endoglin (CD105), a major glycoprotein of human vascular endothelium, is a type I integral membrane protein with a large extracellular region, a hydrophobic transmembrane region, and a short cytoplasmic tail. It also contains an RGD tripeptide that may be important for cellular adhesion. There are two forms of endoglin (S-endoglin and L-endoglin) that differ in the length of their cytoplasmic tails. However, the isoforms may have similar functional activity. When overexpressed in fibroblasts, both form disulfide-linked homodimers via their extracellular domains. Endoglin binds TGF-beta1 and TGF-beta3 by associating with TGF-beta type II receptor and binds BMP-7 by associating with activin type II receptor. Thus, endoglin is an accessory protein of multiple TGF-beta superfamily kinase receptor complexes. Loss of function mutations in the human endoglin gene cause hereditary hemorrhagic telangiectasia, which is characterized by vascular malformations. Deletion of endoglin in mice leads to death due to defective vascular development. Thus, endoglin is an endothelial specific cell surface protein that may regulate angiogenesis through interactions with TGF-beta superfamily kinase receptors. This antibody is routinely tested by western blot analysis.
Synonyms: Endoglin

分子量

95 kDa