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Endoglin 抗体

ENG 适用: 人, 大鼠 WB, FACS, IP, CyTOF 宿主: 小鼠 Monoclonal MEM-226 unconjugated
产品编号 ABIN93939
发货至: 中国
  • 抗原 See all Endoglin (ENG) 抗体
    Endoglin (ENG)
    适用
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    人, 大鼠
    宿主
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    小鼠
    克隆类型
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    单克隆
    标记
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    This Endoglin antibody is un-conjugated
    应用范围
    • 148
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    Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Cytometry by Time of Flight (CyTOF)
    特异性
    The antibody MEM-226 reacts with an extracellular epitope of CD105 (Endoglin), a 90 kDa type I homodimerizing membrane glycoprotein expressed on vascular endothelial cells (small and large vessels), activated monocytes and tissue macrophages, stromal cells of certain tissues including bone marrow, pre-B lymphocytes in fetal marrow and erythroid precursors in fetal and adult bone marrow, it is also present on syncytiotrophoblast on placenta throughout pregnancy.
    交叉反应 (详细)
    Human, Rat
    纯化方法
    Purified by protein-A affinity chromatography.
    纯度
    > 95 % (by SDS-PAGE)
    免疫原
    Recombinant Vaccinia virus containing the human CD105 cDNA.
    克隆位点
    MEM-226
    亚型
    IgG2a
    Top Product
    Discover our top product ENG Primary Antibody
  • 应用备注
    Flow cytometry: Recommended dilution: 1-5 μg/mL.
    Western blotting: Non-reducing conditions.
    限制
    仅限研究用
  • 浓度
    1 mg/mL
    缓冲液
    Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    注意事项
    Do not freeze.
    储存条件
    4 °C
    储存方法
    Store at 2-8°C. Do not freeze.
  • Schmidt, Achermann, Odermatt, Breymann, Mol, Genoni, Zund, Hoerstrup: "Prenatally fabricated autologous human living heart valves based on amniotic fluid derived progenitor cells as single cell source." in: Circulation, Vol. 116, Issue 11 Suppl, pp. I64-70, (2007) (PubMed).

  • 抗原
    Endoglin (ENG)
    别名
    CD105 (ENG 产品)
    别名
    ENG antibody, MGC137842 antibody, DKFZp469D0419 antibody, END antibody, HHT1 antibody, ORW1 antibody, AI528660 antibody, AI662476 antibody, CD105 antibody, S-endoglin antibody, endoglin antibody, ENG antibody, Eng antibody
    背景
    Endoglin,CD105 (endoglin) is a homodimeric transmembrane glycoprotein serving in presence of TGFbetaR-2 as a receptor for TGFbeta-1 and TGFbeta-3. CD105 is highly expressed on endothelial cells and promotes angiogenesis during wound healing, infarcts and in a wide range of tumours and its gene expression is stimulated by hypoxia. CD105 prevents apoptosis in hypoxic endothelial cells and also antagonises the inhibitory effects of TGFbeta-1 on vascular endothelial cell growth and migration. Normal cellular levels of CD105 are required for formation of new blood vessels.,Endoglin, END, ENG, HHT1, ORW1
    基因ID
    2022
    UniProt
    P17813
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