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Caspase 3 抗体 (AA 25-145)

Name: Caspase 3 抗体 (AA 25-145)
SKU: ABIN968342
Availability: OutOfStock

This anti-Caspase 3 antibody is a 小鼠单克隆 antibody detecting Caspase 3 in WB, IP 和 IF. Suitable for 小鼠. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of Caspase-3 on RSV-3T3 lysate. (Caspase 3 抗体 (AA 25-145))

Image no. 3 for anti-Caspase 3 (CASP3) (AA 25-145) antibody (ABIN968342) (Caspase 3 抗体 (AA 25-145))

Western Blotting (WB) image for anti-Caspase 3 (CASP3) (AA 25-145) antibody (ABIN968342) (Caspase 3 抗体 (AA 25-145))

4 images

(5 references)

产品编号 ABIN968342

发货至: 中国

Quick Overview for Caspase 3 抗体 (AA 25-145) (ABIN968342)

抗原

See all Caspase 3 (CASP3) 抗体

Caspase 3 (CASP3)

适用

小鼠

宿主

小鼠

克隆类型

单克隆

标记

This Caspase 3 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunoprecipitation (IP), Immunofluorescence (IF)

克隆位点

46-Caspase

Discover our top product CASP3 Primary Antibody

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AA 25-145

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Mouse CPP32 aa. 25-145

亚型

IgG1
anti-Caspase 3 (CASP3) (AA 60-100) antibody
CASP3 适用: 人, 小鼠, 大鼠, Cow, 山羊 WB, IF (cc) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 67-175) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 220-236), (C-Term) antibody
CASP3 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 11-120) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), FACS, IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 小鼠 Monoclonal 5E1 unconjugated

anti-Caspase 3 (CASP3) (cleaved) antibody
CASP3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (Internal Region) antibody
CASP3 适用: 人, 小鼠, 大鼠, Cow WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (pSer150) antibody
CASP3 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 29-175) antibody
CASP3 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated

anti-Caspase 3 (CASP3) (AA 29-175) antibody
CASP3 适用: 人 WB, IHC, IP, ICC 宿主: 小鼠 Monoclonal C3 unconjugated

说明

Related Products: ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Li, Zhao, He, Kim, Kuharsky, Rabinowich, Chen, Du, Yin: "Relief of extrinsic pathway inhibition by the Bid-dependent mitochondrial release of Smac in Fas-mediated hepatocyte apoptosis." in: The Journal of biological chemistry, Vol. 277, Issue 30, pp. 26912-20, (2002) (PubMed).

Jia, Patwari, Srinivasula, Newland, Fernandes-Alnemri, Alnemri, Kelsey: "Bax translocation is crucial for the sensitivity of leukaemic cells to etoposide-induced apoptosis." in: Oncogene, Vol. 20, Issue 35, pp. 4817-26, (2001) (PubMed).

Hatai, Matsuzawa, Inoshita, Mochida, Kuroda, Sakamaki, Kuida, Yonehara, Ichijo, Takeda: "Execution of apoptosis signal-regulating kinase 1 (ASK1)-induced apoptosis by the mitochondria-dependent caspase activation." in: The Journal of biological chemistry, Vol. 275, Issue 34, pp. 26576-81, (2000) (PubMed).

Liu, Kim, Yang, Jemmerson, Wang: "Induction of apoptotic program in cell-free extracts: requirement for dATP and cytochrome c." in: Cell, Vol. 86, Issue 1, pp. 147-57, (1996) (PubMed).

Fernandes-Alnemri, Litwack, Alnemri: "CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme." in: The Journal of biological chemistry, Vol. 269, Issue 49, pp. 30761-4, (1995) (PubMed).
抗原

Caspase 3 (CASP3)

别名

Caspase-3

背景

Apoptosis, a selective process of genetically programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptotic cells are characterized by loss of cell volume, plasma membrane blebbing, nuclear condensation, chromatin aggregation, and endonucleocytic degradation of DNA into nucleosomal fragments. Caspase-3 (CPP32, Yama, apopain) is a member of the family of cysteine proteases which includes interleukin-1beta-converting enzyme (ICE) and C. elegans protein, Ced-3. An apoptotic signal such as granzyme B of cytotoxic T-cells (CTLs) or ICE-like proteases induces the intracellular cleavage of Caspase-3 from the inactive proform (32kDa) to the active form which consists of the p20, p17, and p12 subunits. The active form of Caspase-3 cleaves several other apoptotic proteins including proteins such as DNA fragmentation factor (DFF). Apoptosis can be inhibited by coexpression of Bcl-2 as well as inhibitors of Caspase-3 or other members of the family of cysteine proteases. This antibody recognizes the mouse 32 kDa pro-Caspase-3 and the p17 cleaved form of Caspase 3 in T cell lymphocytes treated with camptothecin.
Synonyms: CPP32

分子量

32 kDa

途径

Apoptosis, Caspase Cascade in Apoptosis, Sensory Perception of Sound, ER-Nucleus Signaling, Positive Regulation of Endopeptidase Activity, Activated T Cell Proliferation