PP5 抗体 (AA 36-238)
(5 references)Quick Overview for PP5 抗体 (AA 36-238) (ABIN968321)
抗原
See all PP5 (PPP5C) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 36-238
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交叉反应
- 小鼠, 人, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Rat PP5 aa. 36-238
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亚型
- IgG1
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anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibody
PPP5C 适用: 人 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 1G2 unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibodyPPP5C 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 5A8 unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibodyPPP5C 适用: 人, 大鼠, 犬, 猴 WB, IHC, IHC (p), FACS 宿主: 小鼠 Monoclonal 6C2 unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibodyPPP5C 适用: 人, 犬 WB, IHC, IF, IHC (p), FACS 宿主: 小鼠 Monoclonal 5G5 unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) (AA 370-488) antibodyPPP5C 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) (AA 1-499) antibodyPPP5C 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibodyPPP5C 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal 12F7 unconjugated
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibody (HRP)PPP5C 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal 12F7 HRP
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibody (FITC)PPP5C 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal 12F7 FITC
anti-Protein Phosphatase 5, Catalytic Subunit (PPP5C) antibody (Biotin)PPP5C 适用: 人 WB, IF, ICC 宿主: 小鼠 Monoclonal 12F7 Biotin
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions." in: The EMBO journal, Vol. 17, Issue 5, pp. 1192-9, (1998) (PubMed).
: "The serine/threonine phosphatase PP5 interacts with CDC16 and CDC27, two tetratricopeptide repeat-containing subunits of the anaphase-promoting complex." in: The Journal of biological chemistry, Vol. 272, Issue 51, pp. 32011-8, (1998) (PubMed).
: "Serine/threonine protein phosphatase type 5 acts upstream of p53 to regulate the induction of p21(WAF1/Cip1) and mediate growth arrest." in: The Journal of biological chemistry, Vol. 273, Issue 20, pp. 12250-8, (1998) (PubMed).
: "Molecular cloning of a protein serine/threonine phosphatase containing a putative regulatory tetratricopeptide repeat domain." in: The Journal of biological chemistry, Vol. 269, Issue 36, pp. 22586-92, (1994) (PubMed).
: "A novel human protein serine/threonine phosphatase, which possesses four tetratricopeptide repeat motifs and localizes to the nucleus." in: The EMBO journal, Vol. 13, Issue 18, pp. 4278-90, (1994) (PubMed).
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: "The structure of the tetratricopeptide repeats of protein phosphatase 5: implications for TPR-mediated protein-protein interactions." in: The EMBO journal, Vol. 17, Issue 5, pp. 1192-9, (1998) (PubMed).
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- PP5 (PPP5C) (Protein Phosphatase 5, Catalytic Subunit (PPP5C))
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别名
- PP5
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背景
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Phosphorylation and dephosphorylation on serine and threonine residues is critical for signal transduction and the regulation of numerous cellular functions. Phosphorylation levels are modulated by protein kinases and phosphatases. The Ser/Thr phosphatase PP5 (also known as PPT) is a model protein of the fourth subfamily of the PPP-family of phosphatases which includes PP1, PP2A, and PP2B. PP5 is primarily located in the nucleus, demonstrates widespread tissue distribution, and is highly conserved among species. It consists of a C-terminal catalytic domain and an N-terminal TPR (tetratricopeptide repeat) domain which is involved in protein-protein interactions. The TPRs of PP5 mediate protein phosphatase activity. TPRs mediate the interaction of PP5 with various proteins including the hsp90-glucocorticoid receptor complex and the kinase domain of ANP-guanylate cyclase receptor. PP5 is thought to be important in cell growth. For example, it functions upstream of p53 to regulate p21/WAF1/Cip1-mediated G1 growth arrest. Thus, PP5 is a nuclear protein phosphatase that is involved in signaling pathways of cell growth and arrest. This antibody is routinely tested by western blot analysis.
Synonyms: PPT -
分子量
- 58 kDa
抗原
-
