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STIM1 抗体 (AA 25-139)

Name: STIM1 抗体 (AA 25-139)
SKU: ABIN968271
Availability: OutOfStock

This anti-STIM1 antibody is a 小鼠单克隆 antibody detecting STIM1 in WB 和 IF. Suitable for 人, 大鼠和小鼠. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of GOK on rat liver lysate. (STIM1 抗体 (AA 25-139))

Image no. 2 for anti-Stromal Interaction Molecule 1 (STIM1) (AA 25-139) antibody (ABIN968271) (STIM1 抗体 (AA 25-139))

Western Blotting (WB) image for anti-Stromal Interaction Molecule 1 (STIM1) (AA 25-139) antibody (ABIN968271) (STIM1 抗体 (AA 25-139))

3 images

(5 references)

产品编号 ABIN968271

发货至: 中国

Datasheet as PDF

Quick Overview for STIM1 抗体 (AA 25-139) (ABIN968271)

抗原

See all STIM1 抗体

STIM1 (Stromal Interaction Molecule 1 (STIM1))

适用

人, 大鼠, 小鼠

宿主

小鼠

克隆类型

单克隆

标记

This STIM1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF)

克隆位点

44-GOK

Discover our top product STIM1 Primary Antibody

抗原表位
15

15

9

6

5

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 25-139

交叉反应

大鼠, 小鼠

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human GOK aa. 25-139

亚型

IgG2a
anti-Stromal Interaction Molecule 1 (STIM1) (AA 24-685) antibody
STIM1 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 5A2 unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (AA 1-211) antibody
STIM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (C-Term) antibody
STIM1 适用: 人, 大鼠, 小鼠 WB, IP, IHC (p), ICC 宿主: 小鼠 Monoclonal CDN3H4 unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (AA 24-686) antibody
STIM1 适用: 人 WB, IHC (p), IF, EIA 宿主: 小鼠 Monoclonal 5A2 unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (AA 24-686) antibody
STIM1 适用: 人 WB, ELISA, IHC, IHC (p), IF 宿主: 小鼠 Monoclonal 5A2 unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (AA 56-69), (Extracellular) antibody
KO Validated STIM1 适用: 人 WB, IHC, IP, IF, FACS, IC, LCI 宿主: 兔 Polyclonal unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (AA 509-538), (C-Term) antibody
STIM1 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB19222 unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (Middle Region) antibody
STIM1 适用: 人, 大鼠, 小鼠, 犬, Cow, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (AA 509-538) antibody
STIM1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Stromal Interaction Molecule 1 (STIM1) (C-Term) antibody
STIM1 适用: 人, 大鼠, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated

说明

Related Products: ABIN968548, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Hu, Lee, Connors, Johnson, Burn, Su, Landes, Feinberg: "A 2.5-Mb transcript map of a tumor-suppressing subchromosomal transferable fragment from 11p15.5, and isolation and sequence analysis of three novel genes." in: Genomics, Vol. 46, Issue 1, pp. 9-17, (1998) (PubMed).

Overall, Parker, Scarcella, Smith, Dziadek: "Murine Stim1 maps to distal chromosome 7 and is not imprinted." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 9, Issue 8, pp. 657-9, (1998) (PubMed).

Yamauchi, Takeuchi, Overall, Dziadek, Munro, Schreiber: "Structural characteristics of bullfrog (Rana catesbeiana) transthyretin and its cDNA--comparison of its pattern of expression during metamorphosis with that of lipocalin." in: European journal of biochemistry / FEBS, Vol. 256, Issue 2, pp. 287-96, (1998) (PubMed).

Parker, Begley, Smith, Fox: "Molecular cloning of a novel human gene (D11S4896E) at chromosomal region 11p15.5." in: Genomics, Vol. 37, Issue 2, pp. 253-6, (1997) (PubMed).

Sabbioni, Barbanti-Brodano, Croce, Negrini: "GOK: a gene at 11p15 involved in rhabdomyosarcoma and rhabdoid tumor development." in: Cancer research, Vol. 57, Issue 20, pp. 4493-7, (1997) (PubMed).
抗原

STIM1 (Stromal Interaction Molecule 1 (STIM1))

别名

GOK

背景

The human chromosomal region 11p15 has undergone intense analysis because of its association with various malignancies. In particular, the band 11p15.5 contains genes associated with Wilms tumor, Beckwith-Weidemann syndrome, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. One such gene, GOK (Stim 1), was identified near the 5' end of the ribonucleotide reductase subunit 1 gene. Examination of the GOK primary amino acid sequence indicates that it is a typical transmembrane protein with an extracellular N-terminal domain and a cytosolic C-terminal domain. The protein is highly hydrophobic with only a short region of hydrophobicity that likely represents the transmembrane region. The C-terminal portion of GOK shares some small regions of homology with myosin (20% identity). This region of GOK consists of alpha-helices and is thought to adopt a coiled-coil conformation. Although GOK expression has no effect on the growth of certain breast cancer cell lines, it induces death in rhabdomyosarcoma cells. Thus, it is thought to be a recessive tumor suppressor in muscle cells, possibly by functioning as a receptor connected to an apoptotic signaling pathway.
Synonyms: Stim1

分子量

84 kDa

途径

TCR Signaling, BCR Signaling