STAT4 抗体 (AA 136-258)
(3 references)Quick Overview for STAT4 抗体 (AA 136-258) (ABIN968254)
抗原
See all STAT4 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 136-258
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交叉反应
- 大鼠, 小鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Stat4 aa. 136-258
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亚型
- IgG1
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anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 505-737) antibody
STAT4 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 1-748) antibodySTAT4 适用: 人 WB, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 1C2-1C12 unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 600-700) antibodySTAT4 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 569-748) antibodySTAT4 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (pTyr693) antibodySTAT4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) antibodySTAT4 适用: 人 WB, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (N-Term) antibodySTAT4 适用: 人, 小鼠, 大鼠, Pig, 犬, 兔, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (C-Term) antibodySTAT4 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IP, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (pTyr693) antibodySTAT4 适用: 小鼠 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 4 (STAT4) (AA 1-749) antibodySTAT4 适用: 人 WB, IHC, ELISA, IP, IF, IHC (p) 宿主: 小鼠 Monoclonal 1C2-1C12 unconjugated
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说明
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Related Products: ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Interleukin 2 signaling involves the phosphorylation of Stat proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7779-83, (1995) (PubMed).
: "Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation." in: Molecular and cellular biology, Vol. 14, Issue 7, pp. 4342-9, (1994) (PubMed).
: "Stat3 and Stat4: members of the family of signal transducers and activators of transcription." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 11, pp. 4806-10, (1994) (PubMed).
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: "Interleukin 2 signaling involves the phosphorylation of Stat proteins." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 17, pp. 7779-83, (1995) (PubMed).
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- STAT4 (Signal Transducer and Activator of Transcription 4 (STAT4))
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别名
- Stat4
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背景
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The Stat proteins function as both cytoplasmic signal transducers and activators of transcription. Stat91/84 (the two proteins are the result of alternate splicing-Stat91 has an additional 38 C-terminal amino acids) and Stat113 were the first identified members of this protein family. With the discovery of additional members of the Stat family (Stat 3 & 4), the nomenclature has been revised to reflect the order of their discovery. Stat 91, 84, and 113 have become Stat1alpha, Stat1beta, and Stat2, respectively. Stat4 has been reported to be 52% identical to Stat1 and 47% identical to Stat3. Functionally, Stat4 is similar to the other Stat proteins in that it requires tyrosine phosphorylation in order to stimulate its IFN-gamma activated site (GAS) binding activity. Expression of Stat4 appears to be limited to thymus, spleen, and testis. Its expression in several myeloid cell lines is differentially regulated during cellular differentiation. Co-transfection studies using JAK1 or JAK2 expression constructs indicate that Stat4 is a substrate for these kinases.
Synonyms: Signal Transducers and Activators of Transcription-4 -
分子量
- 89 kDa
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途径
- JAK/STAT Signaling
抗原
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