我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

IQGAP1 抗体 (AA 1348-1490)

Name: IQGAP1 抗体 (AA 1348-1490)
SKU: ABIN968063
Availability: OutOfStock

This anti-IQGAP1 antibody is a 小鼠单克隆 antibody detecting IQGAP1 in WB, IHC, IF 和 IP. Suitable for 人, 小鼠, 大鼠和犬. This Primary Antibody has been cited in 5+ publications.

Western blot analysis of IQGAP1 on a human endothelial cell lysate. (IQGAP1 抗体 (AA 1348-1490))

Immunofluorescence staining of WI-38 cells (Human lung fibroblasts, ATCC CCL-75). (IQGAP1 抗体 (AA 1348-1490))

2 images

(5 references)

产品编号 ABIN968063

发货至: 中国

Quick Overview for IQGAP1 抗体 (AA 1348-1490) (ABIN968063)

抗原

See all IQGAP1 抗体

IQGAP1 (IQ Motif Containing GTPase Activating Protein 1 (IQGAP1))

适用

人, 小鼠, 大鼠, 犬

宿主

小鼠

克隆类型

单克隆

标记

This IQGAP1 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

克隆位点

24-IQGAP1

Discover our top product IQGAP1 Primary Antibody

抗原表位
15

8

4

3

2

1

1

1

1

1

1

1

1

1

1

1

1
AA 1348-1490

交叉反应

小鼠, 大鼠, 犬

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human IQGAP1 aa. 1348-1490

亚型

IgG1
anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 611-710) antibody
IQGAP1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2C5 unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 500-750) antibody
IQGAP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 1451-1550) antibody
IQGAP1 适用: 人, 大鼠, 兔 WB, ELISA, IF (p), IF (cc), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) antibody
IQGAP1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (N-Term) antibody
IQGAP1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (N-Term) antibody
IQGAP1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) antibody
IQGAP1 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (N-Term) antibody
IQGAP1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (AA 793-808), (Intracellular) antibody
IQGAP1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-IQ Motif Containing GTPase Activating Protein 1 (IQGAP1) (Internal Region) antibody
Verified IQGAP1 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated

说明

Related Products: ABIN968536, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

250 μg/mL

缓冲液

Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Store undiluted at -20°C.
Mbele, Deloulme, Gentil, Delphin, Ferro, Garin, Takahashi, Baudier: "The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes." in: The Journal of biological chemistry, Vol. 277, Issue 51, pp. 49998-50007, (2002) (PubMed).

Ruiz-Velasco, Lanning, Williams: "The activation of Rac1 by M3 muscarinic acetylcholine receptors involves the translocation of Rac1 and IQGAP1 to cell junctions and changes in the composition of protein complexes containing Rac1, IQGAP1, and actin." in: The Journal of biological chemistry, Vol. 277, Issue 36, pp. 33081-91, (2002) (PubMed).

Li, Wang, Chakladar, Bronson, Bernards: "Gastric hyperplasia in mice lacking the putative Cdc42 effector IQGAP1." in: Molecular and cellular biology, Vol. 20, Issue 2, pp. 697-701, (2000) (PubMed).

Hart, Callow, Souza, Polakis: "IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs." in: The EMBO journal, Vol. 15, Issue 12, pp. 2997-3005, (1996) (PubMed).

Kuroda, Fukata, Kobayashi, Nakafuku, Nomura, Iwamatsu, Kaibuchi: "Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1." in: The Journal of biological chemistry, Vol. 271, Issue 38, pp. 23363-7, (1996) (PubMed).
抗原

IQGAP1 (IQ Motif Containing GTPase Activating Protein 1 (IQGAP1))

别名

IQGAP1

背景

GTPases (Ras, Rho, cdc42Hs, and rac) modulate various cellular functions such as cytoskeletal architecture, growth, motility, and gene expression. The activity of the GTP-binding proteins is regulated by factors that accelerate GTP-binding (GAPs) and proteins that enhance the rate of GTP hydrolysis (GTPases). IQGAP1 is Ras-GAP related protein that contains a WW domain that binds poly-proline regions, a calponin-homology domain (CHD), an IQ domain of unconventional myosins, and a C-terminal GAP-related domain (GRD). IQGAP1 co-immunoprecipitates with cdc42 and calmodulin, and colocalizes with cdc42Hs at the leading edges of the plasma membrane and at the cell-cell junctions. IQGAP1 may interact with both cadherins and catenins leading to dissociation of these proteins from sites of cell adhesion. Thus, IQGAP1 may be a Rac1 and Cdc42 effector that negatively regulates cadherin-mediated cell junctions.

分子量

195 kDa

途径

Signaling Events mediated by VEGFR1 and VEGFR2