BDKRB2 抗体 (AA 350-364)
(5 references)Quick Overview for BDKRB2 抗体 (AA 350-364) (ABIN967978)
抗原
See all BDKRB2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 350-364
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交叉反应
- 大鼠
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
5. For fluorochrome spectra and suitable instrument settings, please refer to us. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human B2 Bradykinin Receptor aa. 350-364
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亚型
- IgG2b kappa
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anti-Bradykinin Receptor B2 (BDKRB2) (AA 51-150) antibody
BDKRB2 适用: 小鼠, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), ICC, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 302-391) antibodyBDKRB2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 336-391) antibodyBDKRB2 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 1-60) antibodyBDKRB2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3F6 unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 1-60) antibodyBDKRB2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (N-Term) antibodyBDKRB2 适用: 人, Cow WB 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (N-Term) antibodyBDKRB2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Bradykinin Receptor B2 (BDKRB2) (AA 336-349), (Intracellular) antibodyBDKRB2 适用: 人 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion." in: BMC physiology, Vol. 3, pp. 1, (2003) (PubMed).
: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, (2002) (PubMed).
: "Activation of NF-kappa B by bradykinin through a Galpha(q)- and Gbeta gamma-dependent pathway that involves phosphoinositide 3-kinase and Akt." in: The Journal of biological chemistry, Vol. 275, Issue 32, pp. 24907-14, (2000) (PubMed).
: "Interaction of endothelial and neuronal nitric-oxide synthases with the bradykinin B2 receptor. Binding of an inhibitory peptide to the oxygenase domain blocks uncoupled NADPH oxidation." in: The Journal of biological chemistry, Vol. 275, Issue 8, pp. 5291-6, (2000) (PubMed).
: "Human bradykinin B2 receptor: nucleotide sequence analysis and assignment to chromosome 14." in: Genomics, Vol. 15, Issue 2, pp. 435-8, (1993) (PubMed).
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: "The bradykinin BK2 receptor mediates angiotensin II receptor type 2 stimulated rat duodenal mucosal alkaline secretion." in: BMC physiology, Vol. 3, pp. 1, (2003) (PubMed).
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- BDKRB2 (Bradykinin Receptor B2 (BDKRB2))
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别名
- B2 Bradykinin Receptor
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背景
- Bradykinin is a nine amino acid vasoactive peptide that elicits numerous physiologic responses such as vasodilation, smooth muscle spasm, and pain. Bradykinin is one of a family of such peptides called the kinins. The kinins are generated from high molecular weight precursors called kininogens from proteolysis induced by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are mediated by their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes: B1 and B2. Both are coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas, the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven helix G-protein coupled receptors. Bradykinin has a relatively low affinity for B1 receptors, and interacts primarily with the B2 receptor. This interaction stimulates several second messenger systems, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.
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分子量
- 42 kDa
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途径
- ACE Inhibitor Pathway, Negative Regulation of intrinsic apoptotic Signaling
抗原
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