NOS1 抗体 (AA 1095-1289)
(5 references)Quick Overview for NOS1 抗体 (AA 1095-1289) (ABIN967894)
抗原
See all NOS1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1095-1289
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交叉反应
- 大鼠, 小鼠, 犬
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human nNOS aa. 1095-1289
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亚型
- IgG2a
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anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (C-Term) antibody
Verified NOS1 适用: 人 IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 53-247) antibodyNOS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 9-136) antibodyNOS1 适用: 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 17-153) antibodyNOS1 适用: 人 ELISA, ICC, FACS 宿主: 小鼠 Monoclonal 2E11G6 unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (pSer852) antibodyNOS1 适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 1213-1337) antibodyNOS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 51-150) antibodyNOS1 适用: 人, 大鼠, 小鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 691-826) antibodyNOS1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (C-Term) antibodyNOS1 适用: 人 WB, IHC 宿主: 山羊 Polyclonal unconjugated
anti-Nitric Oxide Synthase 1, Neuronal (NOS1) (AA 1418-1434), (C-Term) antibodyNOS1 适用: 人, 大鼠, 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Neurochemical phenotypes of myenteric neurons in the rhesus monkey." in: The Journal of comparative neurology, Vol. 519, Issue 17, pp. 3387-401, (2012) (PubMed).
: "The plasmamembrane calmodulin-dependent calcium pump: a major regulator of nitric oxide synthase I." in: The Journal of cell biology, Vol. 155, Issue 2, pp. 201-5, (2001) (PubMed).
: "Dynamic regulation of neuronal NO synthase transcription by calcium influx through a CREB family transcription factor-dependent mechanism." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 97, Issue 15, pp. 8617-22, (2000) (PubMed).
: "Gene transfer of the neuronal NO synthase isoform to cirrhotic rat liver ameliorates portal hypertension." in: The Journal of clinical investigation, Vol. 105, Issue 6, pp. 741-8, (2000) (PubMed).
: "Nitric oxide as a secretory product of mammalian cells." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 6, Issue 12, pp. 3051-64, (1992) (PubMed).
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: "Neurochemical phenotypes of myenteric neurons in the rhesus monkey." in: The Journal of comparative neurology, Vol. 519, Issue 17, pp. 3387-401, (2012) (PubMed).
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- NOS1 (Nitric Oxide Synthase 1, Neuronal (NOS1))
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别名
- nNOS/NOS Type I
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背景
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Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits cellular signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca2+ levels and enhance calmodulin binding. Neuronal NOS (nNOS or bNOS) and endothelial NOS (ECNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin and are regulated in a similar manner. However, both have been shown to be distinct gene products of about 155 kDa and 140 kDa, respectively, and the human forms show 52% amino acid identity. Neuronal NOS and induced macrophage NOS (iNOS) share 51% amino acid homology with the greatest degree of divergence in the calmodulin binding domain. Neuronal NOS, a cytosolic protein present mainly in neural tissues, has been purified and characterized from rat cerebellum. The NO synthesized by this enzyme acts as a neurotransmitter. ECNOS has been cloned from human vascular endothelium as well as from bovine aortic endothelial cells (BAEC) and has a unique N-myristylation consensus sequence that may explain its membrane localization. This antibody is routinely tested by western blot analysis.
Synonyms: NOS Type I, Neuronal Nitric Oxide Synthase -
分子量
- 155 kDa
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途径
- Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction
抗原
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