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ENOS 抗体 (AA 1025-1203)

NOS3 适用: 人, 大鼠, 小鼠 WB, IHC, IF, IP 宿主: 小鼠 Monoclonal 3-eNOS-NOS Type III unconjugated
产品编号 ABIN967886
发货至: 中国
  • 抗原 See all ENOS (NOS3) 抗体
    ENOS (NOS3) (Nitric Oxide Synthase 3 (Endothelial Cell) (NOS3))
    抗原表位
    • 34
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    AA 1025-1203
    适用
    • 265
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    • 14
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    人, 大鼠, 小鼠
    宿主
    • 275
    • 28
    • 1
    小鼠
    克隆类型
    • 277
    • 27
    单克隆
    标记
    • 121
    • 27
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    • 9
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    This ENOS antibody is un-conjugated
    应用范围
    • 255
    • 104
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    Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)
    交叉反应
    小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    5. For fluorochrome spectra and suitable instrument settings, please refer to us.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Human eNOS aa. 1025-1203
    克隆位点
    3-eNOS-NOS Type III
    亚型
    IgG1 kappa
    Top Product
    Discover our top product NOS3 Primary Antibody
  • 说明

    Related Products: ABIN968536, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20°C.
  • Kincer, Uittenbogaard, Dressman, Guerin, Febbraio, Guo, Smart: "Hypercholesterolemia promotes a CD36-dependent and endothelial nitric-oxide synthase-mediated vascular dysfunction." in: The Journal of biological chemistry, Vol. 277, Issue 26, pp. 23525-33, (2002) (PubMed).

    Thomas, Chen, Keaney: "Hydrogen peroxide activates endothelial nitric-oxide synthase through coordinated phosphorylation and dephosphorylation via a phosphoinositide 3-kinase-dependent signaling pathway." in: The Journal of biological chemistry, Vol. 277, Issue 8, pp. 6017-24, (2002) (PubMed).

    Cao, Yao, McCabe, Yao, Katusic, Sessa, Shah: "Direct interaction between endothelial nitric-oxide synthase and dynamin-2. Implications for nitric-oxide synthase function." in: The Journal of biological chemistry, Vol. 276, Issue 17, pp. 14249-56, (2001) (PubMed).

    Laufs, Endres, Stagliano, Amin-Hanjani, Chui, Yang, Simoncini, Yamada, Rabkin, Allen, Huang, Böhm, Schoen, Moskowitz, Liao: "Neuroprotection mediated by changes in the endothelial actin cytoskeleton." in: The Journal of clinical investigation, Vol. 106, Issue 1, pp. 15-24, (2000) (PubMed).

    Zhao, Dugas, Mathiot, Delmer, Dugas, Sigaux, Kolb: "B-cell chronic lymphocytic leukemia cells express a functional inducible nitric oxide synthase displaying anti-apoptotic activity." in: Blood, Vol. 92, Issue 3, pp. 1031-43, (1998) (PubMed).

  • 抗原
    ENOS (NOS3) (Nitric Oxide Synthase 3 (Endothelial Cell) (NOS3))
    别名
    eNOS/NOS Type III (NOS3 产品)
    别名
    ECNOS antibody, eNOS antibody, 2310065A03Rik antibody, Nos-3 antibody, ecNOS antibody, EC-NOS antibody, NOSIII antibody, cNOS antibody, NOS antibody, NOS3 antibody, eNos antibody, ENOS antibody, nitric oxide synthase 3 antibody, nitric oxide synthase 3, endothelial cell antibody, NOS3 antibody, Nos3 antibody, nos3 antibody
    背景
    Nitric oxide synthase (NOS), a cell-type specific enzyme, catalyzes the synthesis of nitric oxide (NO). NO is a short-lived radical that transmits signals involved in vasorelaxation, neurotransmission, and cytotoxicity. In neurons and endothelial cells, constitutive NOS (cNOS) is activated by agonists that increase intracellular Ca[2+] levels and enhance calmodulin binding. Neuronal NOS (mNOS) and endothelial NOS (eNOS) have recognition sites for NADPH, FAD, FMN, and calmodulin and both are regulated in a similar manner. The human forms exhibit 52% amino acid identity. However, they are distinct gene products of about 155 kDa (mNOS) and 140 kDA (eNOS). The eNOS gene was cloned from human vascular endothelium as well as from bovine aortic endothelial cells (BAEC). eNOS protein has a unique N-myristylation consensus sequence that may explain its membrane localization.
    分子量
    140 kDa
    途径
    ACE Inhibitor Pathway, Regulation of Systemic Arterial Blood Pressure by Hormones, Cellular Response to Molecule of Bacterial Origin, Myometrial Relaxation and Contraction, Signaling Events mediated by VEGFR1 and VEGFR2, Thromboxane A2 Receptor Signaling, VEGFR1 Specific Signals, VEGF Signaling
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