CAN 抗体 (AA 247-449)
(5 references)Quick Overview for CAN 抗体 (AA 247-449) (ABIN967861)
抗原
See all CAN 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 247-449
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交叉反应
- 大鼠, 小鼠, 小鸡, Frog
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human Calcineurin aa. 247-449
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亚型
- IgG2a
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anti-Calcineurin (CAN) (AA 7-301) antibody
CAN 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin (CAN) (AA 21-51) antibodyCAN 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcineurin (CAN) (AA 21-51), (N-Term) antibodyCAN 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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说明
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Related Products: ABIN968545, ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20°C.
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: "Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 669-74, (2003) (PubMed).
: "cAMP-dependent protein kinase phosphorylations on tau in Alzheimer's disease." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 19, Issue 17, pp. 7486-94, (1999) (PubMed).
: "Regulation of angiotensin II-induced phosphorylation of STAT3 in vascular smooth muscle cells." in: The Journal of biological chemistry, Vol. 274, Issue 28, pp. 19846-51, (1999) (PubMed).
: "The absence of a major Ca2+ signaling pathway in GABAergic neurons of the hippocampus." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 95, Issue 6, pp. 3245-50, (1998) (PubMed).
: "Role of Ca2+/calmodulin-dependent phosphatase 2B in thrombin-induced endothelial cell contractile responses." in: The American journal of physiology, Vol. 275, Issue 4 Pt 1, pp. L788-99, (1998) (PubMed).
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: "Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 100, Issue 2, pp. 669-74, (2003) (PubMed).
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- CAN (Calcineurin (CAN))
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别名
- Calcineurin
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背景
- Calcineurin is a Ca2+/calmodulin-dependent protein phosphatase. The active enzyme is a heterodimer of a large calmodulin-binding catalytic subunit A (61 kDa) and a smaller Ca2+ binding subunit B (19 kDa). Regions corresponding to the calmodulin-binding site, an autoinhibitory domain, and a putative subunit B binding site have been identified within the large subunit A. The activity of calcineurin is sensitive to immunosuppressants such as cyclosporin A (CsA) and tacrolimus (FK506). The study of FK506-mediated inhibition of nitric oxide formation has revealed that nitric oxide synthase (NOS) is a calcineurin substrate. Calcineurin dephosphorylates NOS and enhances its catalytic activity. Therefore, Calcineurin is an essential mediator for efficient T cell antigen receptor (TCR)-mediated T cell activation.
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分子量
- 61 kDa
抗原
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