PKC epsilon 抗体 (AA 1-175)
(6 references)Quick Overview for PKC epsilon 抗体 (AA 1-175) (ABIN967734)
抗原
See all PKC epsilon (PRKCE) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 1-175
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交叉反应
- 大鼠, 犬, 小鼠, 小鸡
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human PKCepsilon aa. 1-175
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亚型
- IgG2a
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anti-Protein Kinase C, epsilon (PRKCE) (AA 631-737) antibody
PRKCE 适用: 人, 大鼠 WB, ELISA, ICC, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, epsilon (PRKCE) antibodyPRKCE 适用: 人, 猴, 犬 WB, IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 2A12 unconjugated
anti-Protein Kinase C, epsilon (PRKCE) antibodyPRKCE 适用: 人, 猴, 犬 IHC, IF, FACS, IHC (p) 宿主: 小鼠 Monoclonal 1B7 unconjugated
anti-Protein Kinase C, epsilon (PRKCE) (AA 488-737) antibodyPRKCE 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, epsilon (PRKCE) (AA 403-672) antibodyPRKCE 适用: 人 WB, IHC, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, epsilon (PRKCE) antibodyPRKCE 适用: 人, 猴, 犬 WB, IF, FACS 宿主: 小鼠 Monoclonal 2E9 unconjugated
anti-Protein Kinase C, epsilon (PRKCE) (AA 403-672) antibodyPRKCE 适用: 人 WB, IHC, ICC, IP 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Protein Kinase C, epsilon (PRKCE) (AA 53-236) antibodyPRKCE 适用: 人, 小鼠, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Kinase C, epsilon (PRKCE) (AA 301-400) antibodyPRKCE 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Protein Kinase C, epsilon (PRKCE) (AA 206-236), (N-Term) antibodyPRKCE 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 250 μg/mL
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缓冲液
- Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store undiluted at -20° C.
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: "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria." in: Circulation research, Vol. 92, Issue 8, pp. 873-80, (2003) (PubMed).
: "Nitric oxide (NO) induces nitration of protein kinase Cepsilon (PKCepsilon ), facilitating PKCepsilon translocation via enhanced PKCepsilon -RACK2 interactions: a novel mechanism of no-triggered activation of PKCepsilon." in: The Journal of biological chemistry, Vol. 277, Issue 17, pp. 15021-7, (2002) (PubMed).
: "Formation of protein kinase C(epsilon)-Lck signaling modules confers cardioprotection." in: The Journal of clinical investigation, Vol. 109, Issue 4, pp. 499-507, (2002) (PubMed).
: "A requirement for protein kinase C inhibition for calcium-triggered apoptosis in acute lymphoblastic leukemia cells." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 5, Issue 2, pp. 355-60, (1999) (PubMed).
: "Expression of protein kinase C genes in hemopoietic cells is cell-type- and B cell-differentiation stage specific." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 147, Issue 11, pp. 3981-7, (1991) (PubMed).
: "Structural and functional diversities of a family of signal transducing protein kinases, protein kinase C family; two distinct classes of PKC, conventional cPKC and novel nPKC." in: Advances in enzyme regulation, Vol. 31, pp. 287-303, (1991) (PubMed).
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: "Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria." in: Circulation research, Vol. 92, Issue 8, pp. 873-80, (2003) (PubMed).
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- PKC epsilon (PRKCE) (Protein Kinase C, epsilon (PRKCE))
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别名
- PKC epsilon
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背景
- The Protein Kinase C (PKC) family of homologous serine/threonine protein kinases is involved in a number of processes such as growth, differentiation, and cytokine secretion. At least eleven isozymes have been described. These proteins are products of multiple genes and alternative splicing. PKC consists of a single polypeptide chain containing four conserved regions (C) and five variable regions (V). The N-terminal half containing C1, C2, V1, and V2 constitutes the regulatory domain and interacts with PKC activators Ca2], phospholipid, diacylglycerol, or phorbol ester. However, the novel PKC (nPKC) subfamily members (delta,eta, eta, and theta isoforms) and the atypical PKC (aPKC) subfamily members (zeta , iota , and lambda isoforms) are Ca[2+] independent and lack the C2 domain. The PKC pathway represents a major signal transduction system that is activated following ligand-stimulation of transmembrane receptors by hormones, neurotransmitters and growth factors. Expression of the 90 kDa PKCalpha is induced by interferon-alpha. Generally, PKCalpha is expressed at very low levels in normal murine tissues, except brain. Overexpression of PKCalpha leads to increased growth rates and higher cell densities in monolayer cultures. A high level of expression is seen in several hematopoietic cell lines and tumors. This suggests a possible role for PKCalpha in tumorigenesis.
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分子量
- 90 kDa
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途径
- TCR Signaling, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Positive Regulation of Peptide Hormone Secretion, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Actin Filament Polymerization, Myometrial Relaxation and Contraction, Regulation of Carbohydrate Metabolic Process, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling
抗原
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