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Paxillin 抗体 (AA 1-557)

PXN 适用: 人, 小鼠, 大鼠, 小鸡, 犬 WB, IF, IP, IHC (f) 宿主: 小鼠 Monoclonal 349-Paxillin unconjugated
产品编号 ABIN967711
发货至: 中国
  • 抗原 See all Paxillin (PXN) 抗体
    Paxillin (PXN)
    抗原表位
    • 32
    • 26
    • 17
    • 16
    • 11
    • 9
    • 8
    • 7
    • 7
    • 7
    • 5
    • 4
    • 3
    • 3
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
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    AA 1-557
    适用
    • 199
    • 104
    • 72
    • 16
    • 8
    • 7
    • 5
    • 4
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    人, 小鼠, 大鼠, 小鸡, 犬
    宿主
    • 191
    • 27
    • 1
    小鼠
    克隆类型
    • 176
    • 43
    单克隆
    标记
    • 122
    • 10
    • 8
    • 8
    • 8
    • 8
    • 8
    • 8
    • 6
    • 6
    • 4
    • 4
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 1
    This Paxillin antibody is un-conjugated
    应用范围
    • 167
    • 67
    • 41
    • 40
    • 37
    • 28
    • 27
    • 25
    • 18
    • 14
    • 14
    • 6
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    交叉反应
    人, 犬, 小鼠, 大鼠
    产品特性
    1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
    2. Please refer to us for technical protocols.
    3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
    4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
    纯化方法
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    免疫原
    Chicken Paxillin aa. 1-557
    克隆位点
    349-Paxillin
    亚型
    IgG1
    Top Product
    Discover our top product PXN Primary Antibody
  • 说明

    Related Products: ABIN968533, ABIN967389

    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    250 μg/mL
    缓冲液
    Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store undiluted at -20° C.
  • Even-Ram, Maoz, Pokroy, Reich, Katz, Gutwein, Altevogt, Bar-Shavit: "Tumor cell invasion is promoted by activation of protease activated receptor-1 in cooperation with the alpha vbeta 5 integrin." in: The Journal of biological chemistry, Vol. 276, Issue 14, pp. 10952-62, (2001) (PubMed).

    Nikolopoulos, Turner: "Actopaxin, a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion." in: The Journal of cell biology, Vol. 151, Issue 7, pp. 1435-48, (2001) (PubMed).

    van de Water, Houtepen, Huigsloot, Tijdens: "Suppression of chemically induced apoptosis but not necrosis of renal proximal tubular epithelial (LLC-PK1) cells by focal adhesion kinase (FAK). Role of FAK in maintaining focal adhesion organization after acute renal cell injury." in: The Journal of biological chemistry, Vol. 276, Issue 39, pp. 36183-93, (2001) (PubMed).

    Wine, Chapin: "Adhesion and signaling proteins spatiotemporally associated with spermiation in the rat." in: Journal of andrology, Vol. 20, Issue 2, pp. 198-213, (1999) (PubMed).

  • 抗原
    Paxillin (PXN)
    别名
    Paxillin (PXN 产品)
    别名
    AW108311 antibody, AW123232 antibody, Pax antibody, CG18061 antibody, CG18576 antibody, CG31794 antibody, CT40481 antibody, CT42454 antibody, DPaxillin antibody, DPxn antibody, DPxn37 antibody, Dmel\\CG31794 antibody, Dpax antibody, DpaxA antibody, PDLP antibody, dPax antibody, pax antibody, wu:fw71f12 antibody, PXN antibody, LOC100220858 antibody, paxillin antibody, Paxillin antibody, paxillin S homeolog antibody, paxillin a antibody, PXN antibody, Pxn antibody, Pax antibody, pxn.S antibody, pxna antibody, LOC696336 antibody, pxn antibody
    背景
    A number of cytoskeletal proteins are tyrosine phosphorylated in Rous sarcoma virus-transformed chick embryo fibroblasts. One of these is the 68 kDa paxillin protein. Paxillin is a cytoskeletal component that localizes to the focal adhesions at the ends of actin stress fibers. It is also present in the focal adhesions of Madin-Darby canine kidney epithelial cells, but is absent from the cell adherens junctions of these cells. Paxillin purified from chicken gizzard migrates as a diffuse band on SDS-PAGE with molecular weight of 65-70 kDa. It binds to the rod domain of vinculin, another focal adhesion protein. It is thought that phosphorylation of paxillin may have a role in that disassembly of focal adhesions and stress fibers during transformation. This antibody is routinely tested by Western blot analysis.
    分子量
    68 kDa
    途径
    MAPK Pathway, EGFR Signaling Pathway, Response to Growth Hormone Stimulus, Cell-Cell Junction Organization, Maintenance of Protein Location, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGF Signaling
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