MPL 抗体 (Extracellular Domain)
(4 references)Quick Overview for MPL 抗体 (Extracellular Domain) (ABIN967682)
抗原
See all MPL 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- Extracellular Domain
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品牌
- BD Pharmingen™
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Human c-Mpl extracellular domain
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亚型
- IgG1 kappa
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anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 66-260) antibody
MPL 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-175) antibodyMPL 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 1D6B7 unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 FACS, ELISA 宿主: 小鼠 Monoclonal 1H2 unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 311-460) antibodyMPL 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 26-491) antibodyMPL 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (Internal Region) antibodyMPL 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) antibodyMPL 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) (AA 1-635) antibodyMPL 适用: 人 WB, FACS 宿主: 小鼠 Polyclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
anti-Myeloproliferative Leukemia Virus Oncogene (MPL) antibodyMPL 适用: 人 WB, FACS, EIA 宿主: 小鼠 Monoclonal 1H2 unconjugated
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说明
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Related Products: ABIN967389
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." in: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).
: "An agonist murine monoclonal antibody to the human c-Mpl receptor stimulates megakaryocytopoiesis." in: Blood, Vol. 92, Issue 6, pp. 1981-8, (1998) (PubMed).
: "Thrombopoietin and erythropoietin activate inside-out signaling of integrin and enhance adhesion to immobilized fibronectin in human growth-factor-dependent hematopoietic cells." in: Annals of hematology, Vol. 75, Issue 5-6, pp. 207-13, (1998) (PubMed).
: "Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit." in: Blood, Vol. 88, Issue 6, pp. 2026-32, (1996) (PubMed).
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: "Mouse monoclonal antibodies against human c-Mpl and characterization for flow cytometry applications." in: Hybridoma (2005), Vol. 29, Issue 2, pp. 103-13, (2010) (PubMed).
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- MPL (Myeloproliferative Leukemia Virus Oncogene (MPL))
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别名
- CD110
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背景
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The 1.78.1 monoclonal antibody specifically binds to the human Thrombopoietin Receptor (TPO-R) that is also know as the Myeloproliferative leukemia protein (c-Mpl) or CD110. CD110 is a type I transmembrane protein and a member of the hematopoietin receptor family. It is expressed on hematopoietic stem cells, a subfraction of hematopoietic precursor cells, cells of the megakaryocytic lineage and platelets. CD110 serves as a receptor for thrombopoietin. Upon binding of thrombopoietin to CD110, megakaryocyte proliferation and differentiation is induced and stem cells are protected from apoptosis.
Synonyms: C-MPL, MPL, MPLV, TPOR, Thrombopoietin receptor -
分子量
- 65-72 kDa (HEL cells) and 80-90 kDa (Platelets)
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途径
- JAK/STAT Signaling
抗原
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