TBK1 抗体 (pSer172)
(2 references)Quick Overview for TBK1 抗体 (pSer172) (ABIN967614)
抗原
See all TBK1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- pSer172
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品牌
- BD Pharmingen™
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交叉反应 （详细）
- Predicted: Mouse
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产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. -
纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
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免疫原
- Phosphorylated Human TBK1
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亚型
- IgG2b kappa
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anti-TANK-Binding Kinase 1 (TBK1) (AA 440-729) antibody
TBK1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) antibodyTBK1 适用: 人 WB, IP, IF 宿主: 兔 Monoclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (pSer172) antibodyTBK1 适用: 小鼠, 大鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 9-310) antibodyTBK1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 150-181) antibodyTBK1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB16573 unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 364-585) antibodyTBK1 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (C-Term) antibodyTBK1 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 644-661) antibodyTBK1 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 74-123) antibodyTBK1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 猴, Pig, 马, 豚鼠, 斑马鱼, Hamster, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-TANK-Binding Kinase 1 (TBK1) (AA 539-588) antibodyTBK1 适用: 人, 小鼠, 大鼠, Cow, 兔, 犬, 猴, Pig, 马, 豚鼠 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C
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储存方法
- Store undiluted at 4°C.
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: "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." in: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).
: "IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2." in: The Journal of biological chemistry, Vol. 277, Issue 16, pp. 13840-7, (2002) (PubMed).
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: "Phosphorylation of NF-kappaB and IkappaB proteins: implications in cancer and inflammation." in: Trends in biochemical sciences, Vol. 30, Issue 1, pp. 43-52, (2005) (PubMed).
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- TBK1 (TANK-Binding Kinase 1 (TBK1))
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别名
- TBK1
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背景
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NF-kB is a ubiquitously expressed transcription factor that regulates many cytokine and Ig genes. It is involved in immune, inflammatory, viral, and acute phase responses. In most cells, NF-kB is sequestered in an inactive cytoplasmic form via interactions with the inhibitory proteins IkBalpha, IkBbeta, and IkBepsilon. Stimulation induces the release, activation, and nuclear translocation of NF-kB. Release of NF-kB results from the phosphorylation and proteolytic degradation of the IkB proteins. Two cytokine-inducible IkappaB kinases (IKKa and IKKb) phosphorylate and target the IkB proteins for degradation via the ubiquitin pathway. IKKg/NEMO, a third member of the IKK complex, functions as a regulatory subunit and interacts directly with IKKb. TBK1 (TANK-binding kinase 1, also known as T2K or NAK), a protein of 729 amino acids, is another member of the IKK family of kinases regulating NF-kB downstream of the tumor necrosis factor and Toll-like receptor pathways. TBK1 forms a complex with the adaptor proteins TANK (TRAF-associated NF-kB activator) and TRAF2 (TNF-receptor-associated factor 2), and this oligomer is required for activation and phosphorylation of TBK1 at serine 172 (S172).
The J133-1171 monoclonal antibody recognizes the phosphorylated S172 of human TBK1.
Synonyms: T2K, NAK -
分子量
- 80 kDa
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途径
- TLR signaling, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades, SARS-CoV-2 Protein Interactome
抗原
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