(2 references)-
- 抗原 See all XPA 抗体
- XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This XPA antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunoprecipitation (IP)
- 品牌
- BD Pharmingen™
- 产品特性
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1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing. - 纯化方法
- The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
- 免疫原
- Human XPA (His-tagged) Recombinant Protein
- 克隆位点
- 12F5
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product XPA Primary Antibody
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anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (Center) antibody
XPA 适用: 人 WB, IF, IHC (p), IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E4 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 1-273) antibodyXPA 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (Internal Region) antibodyXPA 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 211-260) antibodyXPA 适用: 人, 小鼠 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 221-250), (C-Term) antibodyXPA 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23644 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (AA 185-213), (C-Term) antibodyXPA 适用: 人 WB 宿主: 兔 Polyclonal RB33699 unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) (C-Term) antibodyXPA 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Xeroderma Pigmentosum, Complementation Group A (XPA) antibodyXPA 适用: 人 WB, ELISA, IA 宿主: 小鼠 Monoclonal 5F12 unconjugated
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- 说明
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Related Products: ABIN968535, ABIN967389
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 0.5 mg/mL
- 缓冲液
- Aqueous buffered solution containing ≤0.09 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C
- 储存方法
- Store undiluted at 4° C.
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: "Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein." in: The EMBO journal, Vol. 16, Issue 3, pp. 625-38, (1997) (PubMed).
: "Mammalian DNA nucleotide excision repair reconstituted with purified protein components." in: Cell, Vol. 80, Issue 6, pp. 859-68, (1995) (PubMed).
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: "Open complex formation around a lesion during nucleotide excision repair provides a structure for cleavage by human XPG protein." in: The EMBO journal, Vol. 16, Issue 3, pp. 625-38, (1997) (PubMed).
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- 抗原
- XPA (Xeroderma Pigmentosum, Complementation Group A (XPA))
- 别名
- XPA (XPA 产品)
- 别名
- CG6358 antibody, DhR14 antibody, DhXPA antibody, DmXPA antibody, Dmel\\CG6358 antibody, Dxpa antibody, EG:EG0007.8 antibody, XPAC antibody, XPA_DROME antibody, Xpa antibody, dmXPA antibody, dxpa antibody, XP1 antibody, AI573865 antibody, Xpac antibody, xpac antibody, xxpa antibody, Xeroderma pigmentosum group A-like antibody, XPA, DNA damage recognition and repair factor antibody, xeroderma pigmentosum, complementation group A antibody, xeroderma pigmentosum, complementation group A L homeolog antibody, Xpac antibody, XPA antibody, Xpa antibody, xpa.L antibody
- 背景
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Nucleotide excision repair (NER) is a major pathway by which cells remove UV and chemically induced damage from DNA. The biochemistry of NER is complex and includes recognition of the damaged DNA, formation of incisions ~26-29 nucleotides apart on each side of the damaged DNA, excision of an oligonucleotide carrying the damaged DNA, and synthesis of a repair patch using the opposite DNA strand as a template. The xeroderma pigmentosum (XP) factors are the best characterized components in the NER pathway. They are termed XP-A to -G and are thought to be required for the first steps of the nucleotide excision repair process. XPA is a DNA damage-binding protein and XPC is a single stranded DNA-binding protein. XPB and XPD are DNA helicases that are components of the transcription factor TFIIH. The TFIIH complex is thought to be involved in transcription and NER. XPF is an endonuclease that binds to ERCC1 (for excision repair cross-complementing) and the ERCC1-XPF complex makes the incision 5' to the DNA damage. ERCC1 migrates at a molecular weight of ~36 kDa in SDS-PAGE. XPG is an endonuclease that makes the 3' incision. XPA has been reported to migrate at a molecular weight of 34-40 kDa in SDS-PAGE.
Synonyms: Xeroderma Pigmentosum factor A - 分子量
- 34-40 kDa
- 途径
- DNA Damage Repair
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