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CD74 抗体

Name: CD74 抗体
SKU: ABIN967482
Availability: OutOfStock

This anti-CD74 antibody is a 大鼠单克隆 antibody detecting CD74 in WB, IF, IP, IHC (f), IHC (fro), ICS 和 IHC (zinc). Suitable for 小鼠. This Primary Antibody has been cited in 11+ publications.

(11 references)

产品编号 ABIN967482

发货至: 中国

Datasheet as PDF

Quick Overview for CD74 抗体 (ABIN967482)

抗原

See all CD74 抗体

CD74 (HLA-DR-gamma (CD74))

适用

小鼠

宿主

大鼠

克隆类型

单克隆

标记

This CD74 antibody is un-conjugated

应用范围

Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Intracellular Staining (ICS), Immunohistochemistry (Zinc-fixed Sections) (IHC (zinc))

克隆位点

In-1

Discover our top product CD74 Primary Antibody

品牌

BD Pharmingen™

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

A.TL mouse lymphocytes and B10.A mouse-derived CH1 B-cell lymphoma

亚型

IgG2b kappa
anti-HLA-DR-gamma (CD74) (AA 1-106) antibody
CD74 适用: 人 FACS, WB, ELISA, ICC 宿主: 小鼠 Monoclonal 2D1B3 unconjugated

anti-HLA-DR-gamma (CD74) (AA 78-222) antibody
CD74 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-HLA-DR-gamma (CD74) (AA 64-205) antibody
CD74 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-HLA-DR-gamma (CD74) antibody
CD74 适用: 小鼠, 大鼠 IF, IHC 宿主: 兔 Polyclonal unconjugated

anti-HLA-DR-gamma (CD74) (AA 1-106) antibody
CD74 适用: 人 FACS, WB, ELISA 宿主: 小鼠 Monoclonal 2D1B11 unconjugated

anti-HLA-DR-gamma (CD74) antibody
CD74 适用: 人, 小鼠, Baboon FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal LN-2 unconjugated

anti-HLA-DR-gamma (CD74) (AA 73-232) antibody
CD74 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-HLA-DR-gamma (CD74) antibody
CD74 适用: 人 FACS, WB, IF, IHC, IP, ICC 宿主: 小鼠 Monoclonal PIN-1 unconjugated

anti-HLA-DR-gamma (CD74) (N-Term) antibody
CD74 适用: 人, 小鼠, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated

anti-HLA-DR-gamma (CD74) (AA 65-277) antibody
CD74 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/mL

缓冲液

Aqueous buffered solution containing ≤0.09 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Store undiluted at 4°C.
Nakagawa, Roth, Wong, Nelson, Farr, Deussing, Villadangos, Ploegh, Peters, Rudensky: "Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus." in: Science (New York, N.Y.), Vol. 280, Issue 5362, pp. 450-3, (1998) (PubMed).

Bertolino, Rabourdin-Combe: "The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells." in: Critical reviews in immunology, Vol. 16, Issue 4, pp. 359-79, (1997) (PubMed).

Shachar, Flavell: "Requirement for invariant chain in B cell maturation and function." in: Science (New York, N.Y.), Vol. 274, Issue 5284, pp. 106-8, (1996) (PubMed).

Bodmer, Viville, Benoist, Mathis: "Diversity of endogenous epitopes bound to MHC class II molecules limited by invariant chain." in: Science (New York, N.Y.), Vol. 263, Issue 5151, pp. 1284-6, (1994) (PubMed).

Cresswell: "Assembly, transport, and function of MHC class II molecules." in: Annual review of immunology, Vol. 12, pp. 259-93, (1994) (PubMed).

Elliott, Drake, Amigorena, Elsemore, Webster, Mellman, Flavell: "The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules." in: The Journal of experimental medicine, Vol. 179, Issue 2, pp. 681-94, (1994) (PubMed).

Bikoff, Huang, Episkopou, van Meerwijk, Germain, Robertson: "Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression." in: The Journal of experimental medicine, Vol. 177, Issue 6, pp. 1699-712, (1993) (PubMed).

Naujokas, Morin, Anderson, Peterson, Miller: "The chondroitin sulfate form of invariant chain can enhance stimulation of T cell responses through interaction with CD44." in: Cell, Vol. 74, Issue 2, pp. 257-68, (1993) (PubMed).

Viville, Neefjes, Lotteau, Dierich, Lemeur, Ploegh, Benoist, Mathis: "Mice lacking the MHC class II-associated invariant chain." in: Cell, Vol. 72, Issue 4, pp. 635-48, (1993) (PubMed).

Mehringer, Harris, Kindle, McCourt, Cullen: "Characterization of fragments of the murine Ia-associated invariant chain." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 146, Issue 3, pp. 920-7, (1991) (PubMed).

Koch, Koch, Hämmerling: "Ia invariant chain detected on lymphocyte surfaces by monoclonal antibody." in: Nature, Vol. 299, Issue 5884, pp. 644-5, (1982) (PubMed).
抗原

CD74 (HLA-DR-gamma (CD74))

别名

CD74

背景

The In-1 antibody reacts with CD74, the MHC class II-associated Invariant chain (Ii), expressed in I-A+ cell populations. Although it is predominantly expressed intracellularly, it has also been detected on the cell surface of some B-cell lines and at low levels on a small number of B lymphocytes. In the mouse, alternatively spliced transcripts encode 31-kDa and 41-kDa isoforms, and the cell-surface CD74 has a chondroitin sulfate side chain which allows it to interact with CD44. CD74 is directly involved in the intracellular transport of MHC class II molecules and antigen presentation, and it affects the maturation of T and B lymphocytes.
Synonyms: Ii

途径

Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints