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IRF3 抗体 (AA 56-427)

Name: IRF3 抗体 (AA 56-427)
SKU: ABIN967285
Availability: OutOfStock

IRF3 适用: 人 WB, IF, IP, Inhibition 宿主: 小鼠 Monoclonal SL-12-1 unconjugated

1 image

(8 references)

产品编号 ABIN967285

发货至: 中国

Datasheet as PDF

抗原 See all IRF3 抗体

IRF3 (Interferon Regulatory Factor 3 (IRF3))
抗原表位
18

15

15

14

13

9

8

7

6

5

4

4

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 56-427
适用
143

92

57

31

18

3

2

2

2

2

1

1

1
人
宿主
153

13

2
小鼠
Compatible Secondaries
克隆类型
137

31
单克隆
标记
89

12

9

8

6

6

6

6

6

6

2

2

2

2

2

2

2
This IRF3 antibody is un-conjugated
应用范围
122

69

33

32

29

27

20

12

10

8

6

4

3

1

1
Western Blotting (WB), Immunofluorescence (IF), Immunoprecipitation (IP), Blocking Antibody (Inhibition)

产品特性

1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.

纯化方法

Purified from tissue culture supernatant or ascites by affinity chromatography.

免疫原

Human IRF-3 recombinant fusion protein

克隆位点

SL-12-1

亚型

IgG1

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anti-Interferon Regulatory Factor 3 (IRF3) antibody
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anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-260) antibody
IRF3 适用: 人 WB, IHC, IF, ChIP 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-452) antibody
IRF3 适用: 人 WB, ELISA, IF, IP 宿主: 小鼠 Monoclonal 3C8 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 51-150) antibody
IRF3 适用: 人, 小鼠, 大鼠, 猴, Cow WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1-360) antibody
IRF3 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (C-Term) antibody
IRF3 适用: 人 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (pSer386) antibody
IRF3 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) antibody
IRF3 适用: 人, 小鼠, 大鼠 WB, IHC (p), IF (cc) 宿主: 兔 Monoclonal 4C3 unconjugated

anti-Interferon Regulatory Factor 3 (IRF3) (AA 1268-1341) antibody
IRF3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

应用备注

Clone SL-12.1 can be used for western blot analysis (0.5-2.0 µg/ml). Other reported applications include immunoprecipitation and immunofluorescence microscopy. The antibody will recognize both the nuclear and cytoplasmic forms of IRF-3 and can block IRF-3 DNA binding. Jurkat cells are recommended as a positive control (Cat, No. ABIN968537).

说明

Related Products: ABIN968537, ABIN967389

限制

仅限研究用
状态

Liquid

浓度

0.5 mg/ml

缓冲液

Aqueous buffered solution.

储存液

Sodium azide

注意事项

This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C
Hiscott, Pitha, Genin, Nguyen, Heylbroeck, Mamane, Algarte, Lin: "Triggering the interferon response: the role of IRF-3 transcription factor." in: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 19, Issue 1, pp. 1-13, (1999) (PubMed).

Mamane, Heylbroeck, Génin, Algarté, Servant, LePage, DeLuca, Kwon, Lin, Hiscott: "Interferon regulatory factors: the next generation." in: Gene, Vol. 237, Issue 1, pp. 1-14, (1999) (PubMed).

Ronco, Karpova, Vidal, Howley: "Human papillomavirus 16 E6 oncoprotein binds to interferon regulatory factor-3 and inhibits its transcriptional activity." in: Genes & development, Vol. 12, Issue 13, pp. 2061-72, (1998) (PubMed).

Wathelet, Lin, Parekh, Ronco, Howley, Maniatis: "Virus infection induces the assembly of coordinately activated transcription factors on the IFN-beta enhancer in vivo." in: Molecular cell, Vol. 1, Issue 4, pp. 507-18, (1998) (PubMed).

Au, Moore, Lowther, Juang, Pitha: "Identification of a member of the interferon regulatory factor family that binds to the interferon-stimulated response element and activates expression of interferon-induced genes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 92, Issue 25, pp. 11657-61, (1996) (PubMed).

Darnell, Kerr, Stark: "Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins." in: Science (New York, N.Y.), Vol. 264, Issue 5164, pp. 1415-21, (1994) (PubMed).

Loh, Chang, Fodor, Flavell: "Dissection of the interferon gamma-MHC class II signal transduction pathway reveals that type I and type II interferon systems share common signalling component(s)." in: The EMBO journal, Vol. 11, Issue 4, pp. 1351-63, (1992) (PubMed).

Reich, Evans, Levy, Fahey, Knight, Darnell: "Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 84, Issue 18, pp. 6394-8, (1987) (PubMed).
抗原

IRF3 (Interferon Regulatory Factor 3 (IRF3))

别名

IRF-3 (IRF3 产品)

别名

irf3 antibody, IRF3 antibody, C920001K05Rik antibody, IRF-3 antibody, interferon regulatory factor 3 antibody, interferon regulatory factor 7 antibody, irf3 antibody, IRF3 antibody, irf-3 antibody, Irf3 antibody, IRF7 antibody

背景

Viral infection in mammals can lead to the induction of multiple pathways as part of the host defense mechanism. One of the major pathways activated is the JAK-STAT pathway by various interferons (IFNalpha and IFNbeta). These IFNs exert their influence via transcriptional activation of specific target genes involved in antiviral defense, for example the chemokine ISG15 gene or the major histocompatibility complex class I and II molecules. These genes in turn are regulated by the JAK-STAT signaling pathway and through interferon regulatory factors (IRFs). IRFs are a family of transcription factors that possess a broad range of activities. IRF-3 is one of nine members which all share a common DNA binding domain which binds to an IFN stimulated response element (ISRE) found in the majority of IFN-inducible promoters. The IRF-3 gene expresses a 50 kDa protein which is constitutively expressed in all tissues. The protein undergoes post-translational modification as well as dimerization and is translocated from the cytoplasm to the nucleus upon viral infection or exposure to dsRNA. The antibody recognizes human IRF-3. A purified recombinant IRF-3 fusion protein corresponding to human IRF-3 (amino acids 56-427) was used as the immunogen.

分子量

50 kDa

途径

TLR signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades