TYK2 抗体
(3 references)Quick Overview for TYK2 抗体 (ABIN967218)
抗原
See all TYK2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Ni-NTA purified truncated recombinant Tyk2 expressed in E. Coli strain BL21 (DE3)
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纯化方法
- Crude ascites.
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亚型
- IgG1
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anti-Tyrosine Kinase 2 (TYK2) (AA 276-375) antibody
TYK2 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 6H1 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 276-375) antibodyTYK2 适用: 人 WB, ELISA, IF, IHC (p), IP 宿主: 小鼠 Monoclonal 6G12 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 750-850) antibodyTYK2 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (pTyr1054), (pTyr1055) antibodyTYK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 286-372) antibodyTYK2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 1-1187) antibodyTYK2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) (C-Term) antibodyTYK2 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) antibodyTYK2 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Tyrosine Kinase 2 (TYK2) antibodyTYK2 适用: 人 ELISA 宿主: 小鼠 Monoclonal 8G8B3 unconjugated
anti-Tyrosine Kinase 2 (TYK2) (AA 1020-1069) antibodyTYK2 适用: 人, 小鼠 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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Western Blot: 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. -
限制
- 仅限研究用
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状态
- Liquid
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储存条件
- -20 °C
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: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
: "TYK2 is a key regulator of the surveillance of B lymphoid tumors." in: The Journal of clinical investigation, Vol. 114, Issue 11, pp. 1650-8, (2004) (PubMed).
: "Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 170, Issue 2, pp. 1077-83, (2003) (PubMed).
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: "Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 12, pp. 7263-71, (2006) (PubMed).
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- TYK2 (Tyrosine Kinase 2 (TYK2))
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别名
- Tyk2
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背景
- Tyk2 (tyrosine kinase 2),with 1187-amino acid protein (about 131kDa), belongs to the family of non-receptor janus tyrosine kinases, which also includes Jak1, Jak2, and Jak3. Kinases of the Jak family regulate a spectrum of cellular functions downstream of activated cytokine receptors in the lympho-hematopoietic system. Tyk2 is activated by a variety of cytokines: IFN-alpha, IFN-beta, IL-6, IL-10, IL-12, and IL-13 and promotes IFN-gamma production by Th1-type CD4 cells. Tyk2 can be viewed as a dual-function Jak, mediating both pro-inflammatory and anti-inflammatory cytokine responses. Tyk2 is also an important regulator of lymphoid tumor surveillance.
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基因ID
- 7297
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途径
- JAK/STAT Signaling, Hepatitis C
抗原
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