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KAT5 抗体

This anti-KAT5 antibody is a 单克隆 antibody detecting KAT5 in WB, ELISA 和 IHC. Suitable for 人.
产品编号 ABIN967184
发货至: 中国

Quick Overview for KAT5 抗体 (ABIN967184)

抗原

See all KAT5 抗体
KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

适用

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宿主

请咨询

克隆类型

  • 105
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单克隆

标记

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This KAT5 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 纯化方法

    Crude ascites.

    免疫原

    Ni-NTA purified truncated recombinant TIP60-gst expressed in E. Coli strain BL21 (DE3)

    亚型

    IgG2b
  • 应用备注

    Western Blot: 1: 500- 1: 2,000
    IHC(P): 1: 500- 1: 2,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存条件

    -20 °C
  • 抗原

    KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

    别名

    TIP60

    背景

    HTATIP (HIV-1 Tat interacting protein TIP60, about 60kDa) belongs to the MYST family of histone acetyl transferases (HATs) and was originally isolated as an HIV-1 TAT-interactive protein. HATs play important roles in regulating chromatin remodeling, transcription and other nuclear processes by acetylating histone and nonhistone proteins. The nucleosome, made up of four core histone proteins (H2A, H2B, H3 and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure. There are five major variants of histone H2A: canonical H2A (most abundant), H2A.X, MacroH2A, H2ABbd and H2A.Z. Histone H2A.Z, the most conserved variant across species, functions as both a positive and negative regulator of transcription and is important for chromosome stability. Several homologous protein complexes, such as SWR-C, TIP60 and SRCAP (mammals), have been shown to catalyze the ATPdependent exchange of H2A.Z for H2A in the nucleosome. This protein is a histone acetylase that has a role in DNA repair and apoptosis and is thought to play an important role in signal transduction.

    基因ID

    10524

    途径

    Intracellular Steroid Hormone Receptor Signaling Pathway
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