RPS6KA1 抗体
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北京 101111
Quick Overview for RPS6KA1 抗体 (ABIN966976)
抗原
See all RPS6KA1 抗体适用
宿主
克隆类型
标记
应用范围
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纯化方法
- Crude ascites.
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免疫原
- Ni-NTA purified truncated recombinant RSK1 expressed in E. Coli strain BL21 (DE3)
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亚型
- IgG2a
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应用备注
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Western Blot: 1: 500- 1: 2,000
IHC(P): 1: 500- 1: 2,000
ELISA: Propose dilution 1: 10,000.
Determining optimal working dilutions by titration test. -
限制
- 仅限研究用
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储存条件
- -20 °C
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- RPS6KA1 (Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1))
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别名
- RSK1
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背景
- Rsk1 is a member of a family of 90kDa ribosomal protein S6 kinases, which includes Rsk1, Rsk2 and Rsk3. These are broadly expressed serine / threonine protein kinases activated in response to mitogenic stimuli, including extracellular signal regulated protein kinases Erk1 and Erk2. Rsk1 is activated by MAPK in vitro and in vivo via phosphorylation. Active Rsks appear to play a major role in transcriptional regulation by translocating to the nucleus and phosphorylating c-Fos and CREB. RSK proteins possess two separate kinase domains, the C terminal kinase domain and the N terminal kinase domain, separated by a linker region containing a hydrophobic motif. RSK is activated by many stimuli including growth factors, phorbol esters, cAMP, heat shock, and irradiation.
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基因ID
- 6195
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途径
- MAPK Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
抗原
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