ErbB2/Her2 抗体
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北京 101111
Quick Overview for ErbB2/Her2 抗体 (ABIN966277)
抗原
See all ErbB2/Her2 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- HER2 (Ab-1221/1222) antibody detects endogenous levels of total HER2 protein.
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纯化方法
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
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免疫原
- The antiserum was produced against synthesized non-phosphopeptide derived from human HER2 around the phosphorylation site of tyrosine 1221/1222 (N-L-YP-YP -W).
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应用备注
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WB: 1:500~1:1000
IHC: 1:50~1:100. -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 100ug/100ul.
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缓冲液
- Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Memo mediates ErbB2-driven cell motility." in: Nature cell biology, Vol. 6, Issue 6, pp. 515-22, (2004) (PubMed).
: "ErbB-2 activates Stat3 alpha in a Src- and JAK2-dependent manner." in: The Journal of biological chemistry, Vol. 277, Issue 41, pp. 38486-93, (2002) (PubMed).
: "Tumor-inhibitory antibodies to HER-2/ErbB-2 may act by recruiting c-Cbl and enhancing ubiquitination of HER-2." in: Cancer research, Vol. 60, Issue 13, pp. 3384-8, (2000) (PubMed).
: "The duration of phorbol-inducible ErbB2 tyrosine dephosphorylation parallels that of receptor endocytosis rather than threonine-686 phosphorylation: implications for the physiological role of protein kinase C in growth factor receptor signalling." in: Carcinogenesis, Vol. 19, Issue 11, pp. 2013-9, (1998) (PubMed).
: "Adjacent carboxyterminal tyrosine phosphorylation events identify functionally distinct ErbB2 receptor subsets: implications for molecular diagnostics." in: Experimental cell research, Vol. 241, Issue 2, pp. 467-75, (1998) (PubMed).
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- ErbB2/Her2 (Receptor tyrosine-protein kinase erbB-2 (ErbB2/Her2))
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别名
- HER2
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途径
- RTK signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Skeletal Muscle Fiber Development
抗原
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