GREM1 抗体 (C-Term)
(4 references)Quick Overview for GREM1 抗体 (C-Term) (ABIN966222)
抗原
See all GREM1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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交叉反应
- 小鼠, 大鼠
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交叉反应 （详细）
- No cross reactivity with other proteins.
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产品特性
- Rabbit IgG polyclonal antibody for Gremlin-1 (GREM1) detection. Tested with WB in Human, Mouse, Rat.
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免疫原
- A synthetic peptide corresponding to a sequence at the C-terminal of human Gremlin 1, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
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亚型
- IgG
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anti-Gremlin 1 (GREM1) (AA 101-184) antibody
GREM1 适用: 人, 小鼠, 大鼠 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibodyGREM1 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB2060 unconjugated
anti-Gremlin 1 (GREM1) (AA 26-184) antibodyGREM1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 25-184) antibodyGREM1 适用: 小鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 26-184) antibodyGREM1 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C1 unconjugated
anti-Gremlin 1 (GREM1) (AA 25-184) antibodyGREM1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 75-184) antibodyGREM1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Gremlin 1 (GREM1) (AA 18-184) antibodyGREM1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 27-184) antibodyGREM1 适用: 小鸡 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Gremlin 1 (GREM1) (AA 147-175), (C-Term) antibodyGREM1 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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限制
- 仅限研究用
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状态
- Lyophilized
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溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
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缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
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储存液
- Sodium azide, Thimerosal (Merthiolate)
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- -20 °C
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储存方法
- At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
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: "Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." in: Blood, Vol. 109, Issue 5, pp. 1834-40, (2007) (PubMed).
: "The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein." in: BMC cancer, Vol. 6, pp. 74, (2006) (PubMed).
: "Office-based testing for fecal occult blood: do only in case of emergency." in: Annals of internal medicine, Vol. 142, Issue 2, pp. 146-8, (2005) (PubMed).
: "Skeletal overexpression of gremlin impairs bone formation and causes osteopenia." in: Endocrinology, Vol. 146, Issue 2, pp. 655-65, (2005) (PubMed).
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: "Bone morphogenic protein antagonist Drm/gremlin is a novel proangiogenic factor." in: Blood, Vol. 109, Issue 5, pp. 1834-40, (2007) (PubMed).
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- GREM1 (Gremlin 1 (GREM1))
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别名
- Gremlin-1
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背景
- Gremlin, also known as Drm, is a highly conserved 20. 7-kDa, 184 amino acid glycoprotein part of the DAN family and is a cysteine knot-secreted protein. Skeletal cells synthesize bone morphogenetic proteins (BMPs) and BMP antagonists. And Gremlin is expressed in osteoblasts and opposes BMP effects on osteoblastic differentiation and function in vitro. Gremlin 1 (GREM 1) is known for its antagonistic reaction with BMPs in the TGF beta signaling pathway. This gene inhibits BMP-2, BMP-4, and BMP-7. Inhibition by grem 1 of BMPs in mice allow the expression of fibroblast growth factors (FGFs) 4 and 8 and Sonic hedgehog (SHH) which are necessary for proper limb development. Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH (Its binding site for gremlin 1 was located between residues 61-80 and gremlin 1 binding site for YWHAH was found to be located between residues 1-67). Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.
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途径
- Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location
抗原
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