Desmoglein 4 抗体 (C-Term)
This anti-Desmoglein 4 antibody is a 兔 多克隆 antibody detecting Desmoglein 4 in IHC. Suitable for 人 和 小鼠. This Primary Antibody has been cited in 3+ publications.
(3 references)Quick Overview for Desmoglein 4 抗体 (C-Term) (ABIN966012)
抗原
See all Desmoglein 4 (DSG4) 抗体
Desmoglein 4 (DSG4)
适用
人, 小鼠
宿主
兔
克隆类型
多克隆
标记
This Desmoglein 4 antibody is un-conjugated
应用范围
Immunohistochemistry (IHC)
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抗原表位
- C-Term
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纯化方法
- Purified by antigen-specific affinity chromatography.
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免疫原
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human DSG4(Desmoglein-4 precursor)
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anti-Desmoglein 4 (DSG4) (AA 531-630) antibody
DSG4 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 6E7 unconjugated
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应用备注
- ELISA, Western blotting: 1µg/ml for 2hrs.
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- This antibody is stored in PBS, 50% glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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: "Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle." in: Differentiation; research in biological diversity, Vol. 74, Issue 2-3, pp. 129-40, (2006) (PubMed).
: "Desmoglein 4 mutations underlie localized autosomal recessive hypotrichosis in humans, mice, and rats." in: The journal of investigative dermatology. Symposium proceedings / the Society for Investigative Dermatology, Inc. [and] European Society for Dermatological Research, Vol. 10, Issue 3, pp. 222-4, (2005) (PubMed).
: "Defining the pathogenic involvement of desmoglein 4 in pemphigus and staphylococcal scalded skin syndrome." in: The Journal of clinical investigation, Vol. 114, Issue 10, pp. 1484-92, (2004) (PubMed).
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: "Desmoglein 4 is expressed in highly differentiated keratinocytes and trichocytes in human epidermis and hair follicle." in: Differentiation; research in biological diversity, Vol. 74, Issue 2-3, pp. 129-40, (2006) (PubMed).
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- Desmoglein 4 (DSG4)
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别名
- DSG4 (Desmoglein-4)
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背景
- DSG4(Desmoglein-4) is a component of intercellular desmosome junctions. DSG4 is involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. DSG4 coordinates the transition from proliferation to differentiation in hair follicle keratinocytes. The essential role of desmoglein 4 in skin was established by identifying mutations in families with inherited hypotrichosis, as well as in the lanceolate hair mouse. The human desmoglein 4 gene (DSG4) demonstrates that it is composed of 16 exons spanning approximately 37 kb of 18q12 and is situated between DSG1 and DSG3. Defects in DSG4 are the cause of localized autosomal hypotrichosis (LAH). LAH is an autosomal recessive skin disorder. DSG4 is one of the target molecules recognized by autoantibodies in patients with pemphigus vulgaris. Pemphigus vulgaris is a potentially lethal skin disease in which epidermal blisters occur as the result of the loss of cell-cell adhesion.
抗原
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