c-FOS 抗体 (Middle Region)
Quick Overview for c-FOS 抗体 (Middle Region) (ABIN965712)
抗原
See all c-FOS (c-Fos) 抗体适用
宿主
克隆类型
标记
应用范围
-
-
抗原表位
- Middle Region
-
交叉反应
- 小鼠, 大鼠
-
交叉反应 (详细)
- No cross reactivity with other proteins.
-
产品特性
- Rabbit IgG polyclonal antibody for Proto-oncogene c-Fos (FOS) detection. Tested with WB in Human, Mouse, Rat.
-
免疫原
- A synthetic peptide corresponding to a sequence in the middle region of human C-FOS, identical to the related rat and mouse sequences.< br/>Immunogen was affinity purified.
-
亚型
- IgG
-
-
-
-
限制
- 仅限研究用
-
-
-
状态
- Lyophilized
-
溶解方式
- Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.
-
缓冲液
- Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.
-
储存液
- Sodium azide, Thimerosal (Merthiolate)
-
注意事项
- Avoid repeated freezing and thawing.
-
储存条件
- -20 °C
-
储存方法
- At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
-
-
-
: "Fos and bone cell development: lessons from a nuclear oncogene." in: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, (1996) (PubMed).
: "c-fos is required for malignant progression of skin tumors." in: Cell, Vol. 82, Issue 5, pp. 721-32, (1995) (PubMed).
: "Human c-fos oncogene mapped within chromosomal region 14q21----q31." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 18, pp. 5826-30, (1984) (PubMed).
-
: "Fos and bone cell development: lessons from a nuclear oncogene." in: Trends in genetics : TIG, Vol. 11, Issue 11, pp. 436-41, (1996) (PubMed).
-
- c-FOS (c-Fos) (c-Fos)
-
别名
- Proto-oncogene c-Fos
-
背景
- The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.
-
途径
- S100 Proteins
抗原
-