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BLK 抗体

This anti-BLK antibody is a 单克隆 antibody detecting BLK in WB, ELISA 和 IHC. Suitable for 人. This Primary Antibody has been cited in 1 publication.
产品编号 ABIN965674
发货至: 中国

Quick Overview for BLK 抗体 (ABIN965674)

抗原

See all BLK 抗体
BLK (B Lymphoid Tyrosine Kinase (BLK))

适用

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宿主

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克隆类型

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单克隆

标记

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This BLK antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • 特异性

    Ni-NTA purified truncated recombinant BLK expressed in E. Coli strain BL21 (DE3)

    纯化方法

    Crude ascites.

    亚型

    IgG1
  • 应用备注

    Western Blot: 1: 500- 1: 2,000
    IHC(P): 1: 500- 1: 2,000
    IHC(F): 1: 500- 1: 2,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存条件

    -20 °C
  • Tretter, Ross, Dordai, Desiderio: "Mimicry of pre-B cell receptor signaling by activation of the tyrosine kinase Blk." in: The Journal of experimental medicine, Vol. 198, Issue 12, pp. 1863-73, (2003) (PubMed).

  • 抗原

    BLK (B Lymphoid Tyrosine Kinase (BLK))

    别名

    BLK

    背景

    BLK ( B lymphoid tyrosine kinase), with 505-amino acid protein (about 56KDa), belongs to the Src nonreceptor tyrosine kinases family.Different subcellular localizations of Src-family kinases may be important for the regulation of specific cellular processes such as mitogenesis, cytoskeletal organization, and membrane trafficking.Blk is expressed exclusively by B lymphocytes and it is thought to function in a signal transductory pathway specific to this lineage. B lymphoid expression of an active Blk mutant caused proliferation of B progenitor cells and enhanced responsiveness of these cells to interleukin 7. Thus, sustained activation of Blk induces responses normally associated with the pre-BCR.

    基因ID

    640

    途径

    Positive Regulation of Peptide Hormone Secretion, CXCR4-mediated Signaling Events, Thromboxane A2 Receptor Signaling
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