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ABL2 抗体

This anti-ABL2 antibody is a 小鼠 单克隆 antibody detecting ABL2 in WB, ELISA 和 IF. Suitable for 人 和 小鼠.
产品编号 ABIN965499
发货至: 中国

Quick Overview for ABL2 抗体 (ABIN965499)

抗原

See all ABL2 抗体
ABL2

适用

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人, 小鼠

宿主

  • 82
  • 7
小鼠

克隆类型

  • 75
  • 14
单克隆

标记

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This ABL2 antibody is un-conjugated

应用范围

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Western Blotting (WB), ELISA, Immunofluorescence (IF)

克隆位点

1H1
  • 纯化方法

    Ascitic fluid

    免疫原

    Purified recombinant fragment of ABL2 expressed in E. Coli.

    亚型

    IgG1
  • 应用备注

    Western Bloting: 1/500 - 1/2000.
    Immunofluorescence: 1/200 - 1/1000.
    ELISA: Propose dilution 1/10000.
    Not yet tested in other applications.
    Determining optimal working dilutions by titration test.

    限制

    仅限研究用
  • 状态

    Liquid

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C
  • 抗原

    ABL2

    别名

    ABL2

    背景

    ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
    Synonyms: ARG, ABLL, FLJ22224, FLJ31718, FLJ41441

    分子量

    128kDa

    基因ID

    27
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