UBASH3B 抗体 (C-Term)
(2 references)
Quick Overview for UBASH3B 抗体 (C-Term) (ABIN964881)
抗原
See all UBASH3B (STS1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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Supplier Product No.
- 600-401-870
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Supplier
- Rockland
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原理
- Sts-1 Antibody
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交叉反应 （详细）
- This affinity purified antibody is directed against mouse Sts-1 protein.
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产品特性
- Synonyms: rabbit anti-Sts-1 antibody, Sts1, Sts 1, Ubiquitin-associated and SH3 domain-containing protein B, Cbl interacting protein p70 antibody, Suppressor of T-cell receptor signaling 1, T-cell ubiquitin ligand 2, TULA-2, Tyrosine-protein phosphatase STS1/TULA2, Ubash3B
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纯化方法
- The product was affinity purified from monospecific antiserum by immunoaffinity purification.
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过滤
- Sterile filtered
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免疫原
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Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of mouse Sts-1.
Immunogen Type: Conjugated Peptide
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亚型
- IgG
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anti-Cbl-Interacting Protein Sts-1 (STS1) (AA 1-300) antibody
STS1 适用: 人 IHC, WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Cbl-Interacting Protein Sts-1 (STS1) (AA 344-441) antibodySTS1 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 3G7 unconjugated
anti-Cbl-Interacting Protein Sts-1 (STS1) (AA 1-300) antibodySTS1 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Cbl-Interacting Protein Sts-1 (STS1) antibodySTS1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cbl-Interacting Protein Sts-1 (STS1) antibodySTS1 适用: 人, 小鼠, 大鼠 IHC, WB, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Cbl-Interacting Protein Sts-1 (STS1) (AA 344-442) antibodySTS1 适用: 人 IHC, WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3G7 unconjugated
anti-Cbl-Interacting Protein Sts-1 (STS1) (AA 564-613) antibodySTS1 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, Pig WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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Immunohistochemistry Dilution: 4 μg/mL
Application Note: This affinity purified antibody has been tested for use in ELISA, IHC, and by western blot. Specific conditions for reactivity should be optimized by the end user. Expect a band
Western Blot Dilution: 1:500 - 1:3,000
ELISA Dilution: 1:2,000 - 1:10,000
IF Microscopy Dilution: User Optimized
Other: User Optimized
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.63 mg/mL
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缓冲液
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Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Stabilizer: None
Preservative: 0.01 % (w/v) Sodium Azide -
储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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有效期
- 12 months
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: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).
: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).
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: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).
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- UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))
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别名
- UBASH3B
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背景
- Background: Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.
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基因ID
- 84959, 24497612
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UniProt
- Q8TF42
抗原
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