MANF 抗体
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北京 101111
Quick Overview for MANF 抗体 (ABIN956417)
抗原
See all MANF 抗体适用
宿主
克隆类型
标记
应用范围
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特异性
- Human MANF
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交叉反应 （详细）
- No cross-reactivity in MANF-knock out mouse and with CDNF in IHC, slightly cross-reacts with purified CDNF in WB
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纯化方法
- MANF-affinity purified
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免疫原
- Recombinant human MANF protein produced using CHO-basedIcosagen Cell factory Ltd. proprietary suspension cell line. Immunogen is purifiedfrom cell culture supernatant
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亚型
- IgG
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anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) antibody
MANF 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 28-182) antibodyMANF 适用: 人 WB, IHC 宿主: 小鼠 Monoclonal C2 unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (C-Term) antibodyKO Validated MANF 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 116-185) antibodyMANF 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1D10 unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 25-182) antibodyMANF 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibodyMANF 适用: 人 WB, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (Internal Region) antibodyVerified MANF 适用: 人 WB, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 1-182) antibodyMANF 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) (AA 103-152) antibodyMANF 适用: 人, 小鼠, 大鼠, Cow, 豚鼠, 马, 兔, 斑马鱼, Bat, 小鸡, 猴, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF) antibodyMANF 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1G12 unconjugated
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应用备注
- ELISA1:200 000, Western immunoblotting 1:2000 – 1:6000, IHC, IF. Polyclonal antibody working titer has to be established practically for each particularantigen and assay format
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说明
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Synonym: ARMET, ARP
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.45 mg/ml
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缓冲液
- Concentrated ammonium sulphide in PBS pH 7.4.
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注意事项
- As product is (NH4)2SO4precipitate, mix well by pipetting or vortexing prior use.
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储存条件
- 4 °C
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储存方法
- This product is shipped in non-frozen liquid form in ambient conditions
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: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).
: "Cerebral dopamine neurotrophic factor-deficiency leads to degeneration of enteric neurons and altered brain dopamine neuronal function in mice." in: Neurobiology of disease, Vol. 134, pp. 104696, (2020) (PubMed).
: "MANF Ablation Causes Prolonged Activation of the UPR without Neurodegeneration in the Mouse Midbrain Dopamine System." in: eNeuro, Vol. 7, Issue 1, (2020) (PubMed).
: "MANF Is Essential for Neurite Extension and Neuronal Migration in the Developing Cortex." in: eNeuro, Vol. 4, Issue 5, (2018) (PubMed).
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: "Deficiency of the ER-stress-regulator MANF triggers progressive outer hair cell death and hearing loss." in: Cell death & disease, Vol. 11, Issue 2, pp. 100, (2020) (PubMed).
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- MANF (Mesencephalic Astrocyte-Derived Neurotrophic Factor (MANF))
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别名
- MANF
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背景
- MANF is a trophic factor for midbrain dopamine neuronsin vivo. It prevents the 6-OHDA-induced degeneration of dopamine neurons in rodent models of Parkinson’sdisease (Lindholm et al., 2008, Voutilainen et al., 2009). When administeredafter 6-OHDA-lesioning it restores the dopaminergic function and prevents degenerationof dopamine neurons in substantia nigra pars compacta
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UniProt
- P55145
抗原
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