WWOX 抗体 (C-Term)
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Quick Overview for WWOX 抗体 (C-Term) (ABIN955590)
抗原
See all WWOX 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 368-396, C-Term
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特异性
- This antibody detects WWOX / FOR (C-term).
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交叉反应 (详细)
- Species reactivity (tested):Human, mouse
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纯化方法
- Protein A column followed by peptide affinity purification
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免疫原
- KLH conjugated synthetic peptide between 368-396 amino acids from the C-terminal region of human WWOX
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亚型
- Ig Fraction
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
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- WWOX (WW Domain Containing Oxidoreductase (WWOX))
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别名
- WWOX / FOR
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背景
- WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90 % identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms.Synonyms: FOR I, FOR II, FOR III, FOR IV, FOR1, FOR2, FOR3, Fragile site FRA16D oxidoreductase, WOX1, WOX2, WOX3, WW domain-containing oxidoreductase, WWOXdelta5-8, WWOXdelta6-8, WWOXv1, WWOXv2, WWOXv3, WWOXv4, WWOXv8
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基因ID
- 51741
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NCBI登录号
- NP_057457
抗原
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