Vitamin D Receptor 抗体 (Middle Region)
Quick Overview for Vitamin D Receptor 抗体 (Middle Region) (ABIN955519)
抗原
See all Vitamin D Receptor (VDR) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - AA 273-299, Middle Region
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特异性
 - This antibody detects Vitamin D3 receptor / NR1I1 (Center).
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交叉反应 (详细)
 - Species reactivity (tested):Human
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纯化方法
 - Protein A column followed by peptide affinity purification
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免疫原
 - KLH conjugated synthetic peptide between 273-299 amino acids from the Central region of human VDR
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亚型
 - Ig Fraction
 
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应用备注
 - Optimal working dilution should be determined by the investigator.
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限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 0.25 mg/mL
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缓冲液
 - PBS with 0.09 % (W/V) sodium azide
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储存液
 - Sodium azide
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注意事项
 - This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
 - Avoid repeated freezing and thawing.
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储存条件
 - 4 °C/-20 °C
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储存方法
 - Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.
 
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- Vitamin D Receptor (VDR)
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别名
 - Vitamin D3 Receptor / NR1I1
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物质类
 - Chemical
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背景
 - This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding the same protein.Synonyms: 1, 25-dihydroxyvitamin D3 receptor, Nuclear receptor subfamily 1 group I member 1, VDR
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基因ID
 - 7421
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NCBI登录号
 - NP_000367
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途径
 - Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
 
抗原
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