SREBF2 抗体 (Middle Region)
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Quick Overview for SREBF2 抗体 (Middle Region) (ABIN954950)
抗原
See all SREBF2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 402-431, Middle Region
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特异性
- This antibody recognizes SREBF2 / SREBP2.
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交叉反应 （详细）
- Species reactivity (tested):Human
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纯化方法
- Purified through a Protein A column followed by peptide affinity purification
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免疫原
- Synthetic peptide - KLH conjugated - corresponding to the central region (between 402-431aa) of human SREBF2 / SREBP2
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亚型
- Ig Fraction
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anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 399-427) antibody
SREBF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 75-164) antibodySREBF2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 801-900) antibodySREBF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 434-483) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig, 犬, Cow, 豚鼠, 马, 小鸡, Bat, Hamster, 猴, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 304-353) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig, 犬, Cow, 豚鼠, 马, 小鸡, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 455-469) antibodySREBF2 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 399-427) antibodySREBF2 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB24513 unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) antibodySREBF2 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 441-473) antibodySREBF2 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB49773 unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS with 0.09 % (W/V) Sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
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别名
- SREBF2 / SREBP2
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背景
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol. LS-B1609 polyclonal antibody detects both precursor and active forms of the protein in tissues and cells such as liver, brown fat, testis, Hep-G2 cells, and human fibroblast. The apparent molecular weight on SDS-PAGE may be higher than the calculated molecular weight (about 126 kDa) due to glycosylation of the protein.Synonyms: BHLHD2, Class D basic helix-loop-helix protein 2, SREBP-2, Sterol regulatory element-binding protein 2, Sterol regulatory element-binding transcription factor 2
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基因ID
- 6721
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NCBI登录号
- NP_004590
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途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
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