SREBF2 抗体 (AA 399-427)
Our Local Distributor
北京 101111
Quick Overview for SREBF2 抗体 (AA 399-427) (ABIN654630)
抗原
See all SREBF2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 399-427
-
纯化方法
- This antibody is purified through a protein A column, followed by peptide affinity purification.
-
免疫原
- This SREBF2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 399-427 amino acids from the Central region of human SREBF2.
-
亚型
- Ig Fraction
-
-
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 399-427) antibody
SREBF2 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 75-164) antibodySREBF2 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig WB, IHC (p), IF (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 801-900) antibodySREBF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 434-483) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig, 犬, Cow, 豚鼠, 马, 小鸡, Bat, Hamster, 猴, 兔 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 304-353) antibodySREBF2 适用: 人, 大鼠, 小鼠, Pig, 犬, Cow, 豚鼠, 马, 小鸡, Bat, Hamster, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 455-469) antibodySREBF2 适用: 人 WB, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 402-431), (Middle Region) antibodySREBF2 适用: 人 WB, IF, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) antibodySREBF2 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2) (AA 441-473) antibodySREBF2 适用: 斑马鱼 WB 宿主: 兔 Polyclonal RB49773 unconjugated
-
-
应用备注
- IF: 1:10~50. WB: 1:1000. IHC-P: 1:10~50
-
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
缓冲液
- Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-20 °C
-
储存方法
- Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.
-
有效期
- 6 months
-
-
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
-
别名
- SREBF2
-
背景
- SREBPs, including SREBP-1a, SREBP-1c, and SREBP-2, constitute a family of basic helix-loop-helix (bHLH) transcription factors that play a critical role in lipid homeostasis by regulating genes involved in cholesterol and fatty acid metabolism. Each SREBP consists of three domains, including an amino-terminal transcription factor domain of ~480 amino acids, a middle hydrophobic region of ~80 amino acids containing two hydrophobic transmembrane segments, and a carboxy-terminal regulatory domain of ~590 amino acids. SREBP-2 regulates cholesterol synthesis by activating the transcription of genes for HMG-CoA reductase and other enzymes of the cholesterol synthetic pathway. SREBP-2 is ubiquitously detected in various tissues. Under basal conditions SREBP is bound to ER membranes as a glycosylated precursor protein. Upon cholesterol depletion, the protein is cleaved to its active forms (about 50-68 kDa) and translocated into the nucleus to stimulate transcription of genes involved in the uptake and synthesis of cholesterol.
-
分子量
- 123688
-
基因ID
- 6721
-
NCBI登录号
- NP_004590
-
UniProt
- Q12772
-
途径
- Regulation of Lipid Metabolism by PPARalpha
抗原
-
