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RAD17 抗体 (Middle Region)

This anti-RAD17 antibody is a 兔 多克隆 antibody detecting RAD17 in WB, FACS 和 EIA. Suitable for 人.
产品编号 ABIN954430
发货至: 中国

Quick Overview for RAD17 抗体 (Middle Region) (ABIN954430)

抗原

See all RAD17 抗体
RAD17

适用

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宿主

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克隆类型

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多克隆

标记

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This RAD17 antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)
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    AA 225-254, Middle Region

    特异性

    This antibody recognizes Human RAD17 (Center).

    纯化方法

    Affinity Chromatography on Protein A

    免疫原

    KLH conjugated synthetic peptide between 225-254 amino acids from the Central region of Human RAD17

    亚型

    Ig Fraction
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS, 0.09 % Sodium Azide

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    RAD17

    别名

    RAD17

    背景

    The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.Synonyms: Cell cycle checkpoint protein RAD17, R24L, RF-C/activator 1 homolog

    分子量

    77055 Da

    基因ID

    5884

    NCBI登录号

    NP_002864
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