PNN 抗体 (Middle Region)
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Quick Overview for PNN 抗体 (Middle Region) (ABIN954147)
抗原
See all PNN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 216-248, Middle Region
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特异性
- This antibody recognizes Human Pinin / PNN (Center).
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纯化方法
- Affinitty Chromatography on Protein A
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免疫原
- KLH conjugated synthetic peptide between 216-248 amino acids from the Central region of human PNN.
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亚型
- Ig Fraction
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- PNN (Pinin, Desmosome Associated Protein (PNN))
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别名
- Pinin / PNN
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背景
- Transcriptional activator binding to the E-box 1 core sequence of the E-cadherin promoter gene, the core-binding sequence is 5'CAGGTG-3'. Capable of reversing CTBP1-mediated transcription repression. Component of a splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of a few core proteins and several more peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Participates in the regulation of alternative pre-mRNA splicing. Associates to spliced mRNA within 60 nt upstream of the 5'-splice sites. Involved in the establishment and maintenance of epithelia cell-cell adhesion. Potential tumor suppressor for renal cell carcinoma.Synonyms: 140 kDa nuclear and cell adhesion-related phosphoprotein, DRS, DRSP, Desmosome-associated protein, Domain-rich serine protein, MEMA, Nuclear protein SDK3
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分子量
- 81614 Da
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基因ID
- 5411
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NCBI登录号
- NP_002678
抗原
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