FZD6 抗体 (Middle Region)
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Quick Overview for FZD6 抗体 (Middle Region) (ABIN952410)
抗原
See all FZD6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 493-520, Middle Region
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特异性
- This antibody recognizes Human FZD6 (Center).
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纯化方法
- Protein A column, followed by peptide affinity purification
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免疫原
- KLH conjugated synthetic peptide between 493-520 amino acids from the Central region of human FZD6
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亚型
- Ig Fraction
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.25 mg/mL
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缓冲液
- PBS containing 0.09 % (W/V) Sodium Azide as preservative
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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- FZD6 (Frizzled Family Receptor 6 (FZD6))
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别名
- FZD6
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背景
- This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of apoptosis. Alternative splicing results in multiple transcript variants.Synonyms: Frizzled-6, Fz-6, hFz6
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分子量
- 79292 Da
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基因ID
- 8323
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NCBI登录号
- NP_001158087
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途径
- WNT signaling, Tube Formation
抗原
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