Recent experiments show that this antibody (clone 15F.10E5) only binds to differentiated Th1 cells but not Th2 or Th0 cells. It also suppressed both antigen-specific T cell expansion and an autoimmune disease (EAE) mediated by effector Th1 cells.
免疫原
AE7 cells Donor: Lewis rat Fusion Partner: SP 2/0 myeloma
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
浓度
0,1 mg/mL
缓冲液
PBS containing 0.02 % sodium azide (NaN3) as preservative and EIA grade BSA as a stabilizing protein to bring total protein concentration to 4-5 mg/mL.
储存液
Sodium azide
注意事项
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
注意事项
Avoid repeated freezing and thawing.
储存条件
4 °C/-20 °C
储存方法
Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
CD226 (also called DNAM-1) is constituitively expressed on naive CD8+ T cells, as well as subsets of naive CD11b+ macrophages and NK cells. It is also found on a lower percentage (~40 % ) of unactivated CD4+ T cells. CD226 is functional upon T cell activation, and CD226 ligands (CD112 and CD155) are the same in the mouse as for human (Tage-4 is the mouse homologue of CD155). The gene for mouse DNAM-1 was identified on chromosome 18, and the predicted amino acid sequence shows a 53 % homology with human DNAM-1.Synonyms: DNAM-1, DNAX accessory molecule 1