TEK 抗体 (AA 23-737)
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Quick Overview for TEK 抗体 (AA 23-737) (ABIN951225)
抗原
See all TEK 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 23-737
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特异性
- Recognizes TIE-2 (CD202b/TEK)
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交叉反应 (详细)
- Species reactivity (tested):Mouse, Human (Weak).
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纯化方法
- Protein A Chromatography
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免疫原
- Highly pure (>95%) recombinant Mouse soluble TIE-2 (Ala23-Ala737) derived from Insect cells.
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亚型
- IgG
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- PBS, pH 7.2
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储存条件
- 4 °C/-20 °C
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储存方法
- The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
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有效期
- 6 months
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- TEK (TEK Tyrosine Kinase, Endothelial (TEK))
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别名
- CD202b / TEK
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背景
- Recombinant Mouse soluble TIE-1 was fused with a 6x His-tag at the C-terminus. The soluble receptor protein consists of the full extracellular domain (Ser22-Ala748). Mouse sTIE-1 monomer has a calculated molecular mass of approximately 79,8 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 95 kDa protein in SDS-PAGE under reducing conditions. TIE-1 (tyrosine kinase with Ig and EGF homology domains 1) and TIE-2/Tek comprise a receptor tyrosine kinase (RTK) subfamily with unique structural characteristics: two immunoglobulin-like domains flanking three epidermal growth factor (EGF)-like domains and followed by three fibronectin type III-like repeats in the extracellular region and a split tyrosine kinase domain in the cytoplasmic region. These receptors are expressed primarily on endothelial and hematopoietic progenitor cells and play critical roles in angiogenesis, vasculogenesis and hematopoiesis.Synonyms: Angiopoietin-1 receptor, TIE-2, TIE2, Tunica interna endothelial cell kinase, Tyrosine-protein kinase receptor TEK, Tyrosine-protein kinase receptor TIE-2, p140 TEK
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基因ID
- 7010
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NCBI登录号
- NP_000450
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途径
- RTK signaling, Growth Factor Binding
抗原
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