BMP7 抗体 (AA 316-431)
Quick Overview for BMP7 抗体 (AA 316-431) (ABIN950669)
抗原
See all BMP7 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 316-431
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特异性
- Recognizes Human BMP7.
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交叉反应 （详细）
- Species reactivity (tested):Human.
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纯化方法
- Protein A Chromatography
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免疫原
- Highly pure (>95%) recombinant Human BMP-7 (Ala316-His431) derived from E. coli.
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亚型
- IgG
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anti-Bone Morphogenetic Protein 7 (BMP7) (AA 1-431) antibody
BMP7 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal M1-F8 unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 132-431) antibodyBMP7 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 239-431) antibodyBMP7 适用: 人, 小鼠 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 6E5D12 unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (N-Term) antibodyBMP7 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, Pig, 豚鼠, 马 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 293-350) antibodyBMP7 适用: 小鼠, 大鼠, 犬, 兔 WB, ELISA, IHC (p), IF (p), IF (cc), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 293-431) antibodyBMP7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (N-Term) antibodyBMP7 适用: 人, 小鼠, 大鼠, 犬, 兔, Cow, 豚鼠, 马, 绵羊, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 15-44) antibodyBMP7 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 280-309) antibodyBMP7 适用: 人, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Bone Morphogenetic Protein 7 (BMP7) (AA 123-393) antibodyBMP7 适用: Cow WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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溶解方式
- Centrifuge vial prior to opening. Restore in sterile water to a concentration of 0.1-1.0 mg/mL.
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缓冲液
- PBS, pH 7.2
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储存条件
- 4 °C/-20 °C
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储存方法
- The lyophilized antibody is stable at RT for up to 1 month. The reconstituted antibody is stable for at least two weeks at 2-8 °C. Frozen aliquots are stable for at least 6 months when stored at -20 °C. Avoid repeated freeze-thaw cycles!
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有效期
- 6 months
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- BMP7 (Bone Morphogenetic Protein 7 (BMP7))
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别名
- BMP7
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背景
- Bone morphogenetic protein 7 (BMP-7), also known as osteogenic protein 1 (OP1), is a widely expressed TGFβ superfamily member with important functions during embryogenesis, in the adult, and in disease (1,2). Human BMP-7 is synthesized with a 29 amino acid (aa) signal sequence, a 263 aa propeptide, and a 139 aa growth factor domain (3). The growth factor domain of human BMP-7 shares 98 % aa sequence identity with mouse and rat BMP-7. The BMP-7 propeptide is cleaved intracellularly but often remains associated with the mature C-terminus. Based on in vivo and in vitro studies, BMP-7 has the potential to be secreted as a disulfide-linked mature homodimer, or particularly as a heteromeric complex that consists of two propeptides noncovalently associated with a mature disulfide linked homodimer (5,6). The presence of the propeptides in BMP-7 appears to stabilize the molecule and provide a docking mechanism for extracellular storage on molecules such as fibrillin1 and 2 (5,6). The propeptides themselves do not impart latency to the complex. BMP-7 binding to type II receptors rapidly displaces the prodomain: mature molecule interaction and has no effect on activity. But it is suggested that immobilized BMP-7 (via prodomain:fibrillin) is inactive, allowing for possible long term storage of the molecule (6). BMP-7 interacts with the type 2 receptors Activin RIIA, Activin RIIB, and BMPRII and the type 1 receptors Activin RIA, BMPRIA, and BMPRIB (2,6). BMP-7 may also be processed into a disulfide-linked heterodimer with either BMP-2 or BMP-4. Such complexes may show increased potency and range of activity compared to BMP7 homodimers (7-9). BMP-7 plays a role in a variety of organ systems. It promotes new bone formation and nephron development (10,11), inhibits the branching of prostate epithelium (12), and antagonizes epithelial mesenchymal transition (EMT) (13-15). In pathological conditions, BMP-7 inhibits tumor growth and metastasis (14), ameliorates fibrotic damage in nephritis (13), and promotes neuro regeneration following brain ischemia (16).Synonyms: BMP-7, Bone morphogenetic protein 7, OP1, Osteogenic protein 1
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基因ID
- 655
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NCBI登录号
- NP_001710
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途径
- Steroid Hormone Mediated Signaling Pathway, Stem Cell Maintenance
抗原
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