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BAG4 抗体 (C-Term)

This anti-BAG4 antibody is a 兔 多克隆 antibody detecting BAG4 in WB 和 EIA. Suitable for 人.
产品编号 ABIN950598
发货至: 中国

Quick Overview for BAG4 抗体 (C-Term) (ABIN950598)

抗原

See all BAG4 抗体
BAG4 (BCL2-Associated Athanogene 4 (BAG4))

适用

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宿主

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克隆类型

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多克隆

标记

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This BAG4 antibody is un-conjugated

应用范围

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Western Blotting (WB), Enzyme Immunoassay (EIA)
  • 抗原表位

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    AA 380-409, C-Term

    特异性

    This antibody reacts to BAG4.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography on Protein A

    免疫原

    KLH conjugated synthetic peptide between 380-409 amino acids from the C-terminal region of human BAG4

    亚型

    Ig Fraction
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS containing 0.09 % (W/V) sodium azide as preservative

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    BAG4 (BCL2-Associated Athanogene 4 (BAG4))

    别名

    BAG4

    背景

    BAG4 is a member of the BAG1-related protein family. BAG1 is an anti-apoptotic protein that functions through interactions with a variety of cell apoptosis and growth related proteins including BCL-2, Raf-protein kinase, steroid hormone receptors, growth factor receptors and members of the heat shock protein 70 kDa family. This protein contains a BAG domain near the C-terminus, which could bind and inhibit the chaperone activity of Hsc70/Hsp70. This protein was found to be associated with the death domain of tumor necrosis factor receptor type 1 (TNF-R1) and death receptor-3 (DR3), and thereby negatively regulates downstream cell death signaling. The regulatory role of this protein in cell death was demonstrated in epithelial cells which undergo apoptosis while integrin mediated matrix contacts are lost.Synonyms: BAG family molecular chaperone regulator 4, BAG-4, Bcl-2-associated athanogene 4, SODD, Silencer of death domains

    基因ID

    9530

    NCBI登录号

    NP_004865

    途径

    Regulation of Actin Filament Polymerization
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