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Aspartate beta Hydroxylase 抗体 (Middle Region)

This anti-Aspartate beta Hydroxylase antibody is a 兔 多克隆 antibody detecting Aspartate beta Hydroxylase in WB, IHC (p) 和 EIA. Suitable for 人.
产品编号 ABIN950540
发货至: 中国

Quick Overview for Aspartate beta Hydroxylase 抗体 (Middle Region) (ABIN950540)

抗原

See all Aspartate beta Hydroxylase (ASPH) 抗体
Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

适用

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宿主

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克隆类型

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多克隆

标记

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This Aspartate beta Hydroxylase antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)
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    AA 301-331, Middle Region

    特异性

    This antibody reacts to ASPH.

    交叉反应 (详细)

    Species reactivity (tested):Human.

    纯化方法

    Affinity chromatography on Protein A

    免疫原

    KLH conjugated synthetic peptide between 301-331 amino acids from the Central region of human ASPH

    亚型

    Ig Fraction
  • 应用备注

    Optimal working dilution should be determined by the investigator.

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    0.25 mg/mL

    缓冲液

    PBS containing 0.09 % (W/V) sodium azide as preservative

    储存液

    Sodium azide

    注意事项

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid repeated freezing and thawing.

    储存条件

    4 °C/-20 °C

    储存方法

    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • 抗原

    Aspartate beta Hydroxylase (ASPH) (Aspartate beta-Hydroxylase (ASPH))

    别名

    ASPH

    背景

    This gene is thought to play an important role in calcium homeostasis. The gene is expressed from two promoters and undergoes extensive alternative splicing. The encoded set of proteins share varying amounts of overlap near their N-termini but have substantial variations in their C-terminal domains resulting in distinct functional properties. The longest isoforms (a and f) include a C-terminal Aspartyl/Asparaginyl beta-hydroxylase domain that hydroxylates aspartic acid or asparagine residues in the epidermal growth factor (EGF)-like domains of some proteins, including protein C, coagulation factors VII, IX, and X, and the complement factors C1R and C1S. Other isoforms differ primarily in the C-terminal sequence and lack the hydroxylase domain, and some have been localized to the endoplasmic and sarcoplasmic reticulum. Some of these isoforms are found in complexes with calsequestrin, triadin, and the ryanodine receptor, and have been shown to regulate calcium release from the sarcoplasmic reticulum. Some isoforms have been implicated in metastasis.Synonyms: ASP beta-hydroxylase, Aspartate beta-hydroxylase, Aspartyl/asparaginyl beta-hydroxylase, HAAH, JCTN, Peptide-aspartate beta-dioxygenase, junctin

    基因ID

    444

    NCBI登录号

    NP_001158222

    途径

    Positive Regulation of Endopeptidase Activity
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