Amyloid Fibrils 抗体
Cited in 3+ publications.
The 兔 多克隆 anti-Amyloid Fibrils antibody (ABIN950406) specifically detects Amyloid Fibrils in WB, DB, IP, EIA, IHC (fro) 和 IF.
The antibody is reactive with 人 samples.
(3 references)
产品编号 ABIN950406
发货至:
中国
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Quick Overview for Amyloid Fibrils 抗体 (ABIN950406)
抗原
Amyloid Fibrils
适用
人
宿主
兔
克隆类型
多克隆
标记
非结合性
应用范围
Western Blotting (WB), Dot Blot (DB), Immunoprecipitation (IP), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF)
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交叉反应 （详细）
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Species reactivity (expected):Mouse and Rat.
Species reactivity (tested):Human. -
纯化方法
- Protein A Chromatography
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免疫原
- Fibrils prepared from Human Abeta42 peptide.
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亚型
- IgG
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anti-Amyloid Fibrils antibody
适用: 人, 小鼠, 大鼠 WB, DB, ELISA, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Amyloid Fibrils antibody适用: 人 WB, DB, ELISA, IHC, IP, IF/ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 0.5 mg/mL
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缓冲液
- PBS, 0.09 % Sodium Azide, 50 % Glycerol
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储存液
- Sodium azide
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注意事项
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid repeated freezing and thawing.
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储存条件
- 4 °C/-20 °C
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储存方法
- Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
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: "The polyphenol (-)-epigallocatechin-3-gallate prevents apoA-IIowa amyloidosis in vitro and protects human embryonic kidney 293 cells against amyloid cytotoxicity." in: Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis, Vol. 23, Issue 1, pp. 17-25, (2016) (PubMed).
: "DBA/2J genetic background exacerbates spontaneous lethal seizures but lessens amyloid deposition in a mouse model of Alzheimer's disease." in: PLoS ONE, Vol. 10, Issue 5, pp. e0125897, (2016) (PubMed).
: "MEK guards proteome stability and inhibits tumor-suppressive amyloidogenesis via HSF1." in: Cell, Vol. 160, Issue 4, pp. 729-44, (2015) (PubMed).
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- Amyloid Fibrils
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背景
- Amyloid monomeric proteins can sometimes oligomerize into destructive amyloid fibrils. Amyloidogenic conformations of non-disease related proteins can be created by partial protein misfolding or denaturation. Many degenerative diseases are known to be related to the accumulation of misfolded proteins as amyloid fibres (1, 2). These include the amyloid-β peptide plaques and tau neurofibrillary tangles in senile plaques of Alzheimer's symptomology, the deposition of α-synuclein in the Lewy bodies of Parkinson's disease, and accumulation of polyglutamine-containing aggregates in Huntington's disease (2, 3).Synonyms: Fibrils, OC
抗原
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