SIT1 抗体
Cited in 2+ publications. This 小鼠 单克隆 anti-SIT1 antibody (Clone SIT-01) specifically detects SIT1 in WB, IP 和 ICFC. The antibody is reactive with 人 samples.
(2 references)
产品编号 ABIN94465
发货至:
中国
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Quick Overview for SIT1 抗体 (ABIN94465)
抗原
See all SIT1 抗体
SIT1
(Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
适用
人
宿主
小鼠
克隆类型
单克隆
标记
This SIT1 antibody is un-conjugated
应用范围
Western Blotting (WB), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC)
克隆位点
SIT-01
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原理
- Anti-SIT Purified
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特异性
- The antibody SIT-01 reacts with an intracellular epitope of SHP2-interacting transmembrane adaptor protein (SIT) expressed exclusively in lymphoid organs. It weakly crossreacts with murine SIT.
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交叉反应 （详细）
- Human
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纯化方法
- Purified by protein-A affinity chromatography.
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纯度
- > 95 % (by SDS-PAGE)
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免疫原
- Bacterially produced recombinant intracellular fragment of human SIT.
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亚型
- IgG1
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anti-Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1) antibody (PE)
SIT1 适用: 人 ICFC 宿主: 小鼠 Monoclonal SIT-01 PE
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应用备注
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Flow cytometry: Recommended dilution: 1-5 μg/mL, intracellular staining.
Western blotting: Recommended dilution: 1-2 μg/mL, reducing conditions. -
限制
- 仅限研究用
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浓度
- 1 mg/mL
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缓冲液
- Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Do not freeze.
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储存条件
- 4 °C
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储存方法
- Store at 2-8°C. Do not freeze.
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- SIT1 (Signaling threshold Regulating Transmembrane Adaptor 1 (SIT1))
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别名
- SIT
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背景
- Signaling threshold regulating transmembrane adapt,SIT is a 21 kDa transmembrane adaptor protein expressed exclusively in lymphoid organs. It acts either as a positive or as a negative regulatory element in T cell activation and in T cell development. Binding to Grb2 plays a pivotal role in signal transduction. Hubener et al. (2001) determined that the SIT gene contains 5 exons and spans 1.8 kb of genomic DNA. The SIT promoter demonstrated strong transcriptional activity and potential binding sites for both ubiquitous and lymphoid-specific transcription factors.,SIT1
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基因ID
- 27240
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UniProt
- Q9Y3P8
抗原
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